海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2014年
19期
2864-2865
,共2页
EB病毒%感染%鼻咽癌
EB病毒%感染%鼻嚥癌
EB병독%감염%비인암
EB virus%Infection%Nasopharyngeal carcinoma
目的：了解肇庆地区健康体检人群EB病毒的感染状况，为临床鼻咽癌的早期诊断提供依据。方法选取2011-2012年在本院进行健康体检的8550例健康体检者作为观察组，以同期入院治疗的300例鼻咽癌患者作为对照组，采用酶联免疫吸附试验(ELISA)检测并比较两组患者EB病毒抗体的阳性情况。结果(1)观察组患者共检查出EB-VCA-IgA阳性324例，阳性率为3.79%，EB-NA1-IgA阳性140例，阳性率为1.64%，EB-EA-IgG阳性150例，阳性率为1.75%；上述三项指标均明显低于对照组，差异有统计学意义(P<0.05)；(2) EB-VCA-IgA、EB-NA1-IgA和EB-EA-IgG的阳性情况均与鼻咽癌的发生呈正相关关系，且优势比OR值分别为7.875、4.998、4.823。结论本地区健康体检人群EB-VCA-IgA的阳性率最高，EB-EA-IgG阳性率次之，EB-NA1-IgA阳性率最低，且EB-VCA-IgA阳性患者发生鼻咽癌的风险更高，对EB病毒抗体进行检测具有重要的临床意义。
目的：瞭解肇慶地區健康體檢人群EB病毒的感染狀況，為臨床鼻嚥癌的早期診斷提供依據。方法選取2011-2012年在本院進行健康體檢的8550例健康體檢者作為觀察組，以同期入院治療的300例鼻嚥癌患者作為對照組，採用酶聯免疫吸附試驗(ELISA)檢測併比較兩組患者EB病毒抗體的暘性情況。結果(1)觀察組患者共檢查齣EB-VCA-IgA暘性324例，暘性率為3.79%，EB-NA1-IgA暘性140例，暘性率為1.64%，EB-EA-IgG暘性150例，暘性率為1.75%；上述三項指標均明顯低于對照組，差異有統計學意義(P<0.05)；(2) EB-VCA-IgA、EB-NA1-IgA和EB-EA-IgG的暘性情況均與鼻嚥癌的髮生呈正相關關繫，且優勢比OR值分彆為7.875、4.998、4.823。結論本地區健康體檢人群EB-VCA-IgA的暘性率最高，EB-EA-IgG暘性率次之，EB-NA1-IgA暘性率最低，且EB-VCA-IgA暘性患者髮生鼻嚥癌的風險更高，對EB病毒抗體進行檢測具有重要的臨床意義。
목적：료해조경지구건강체검인군EB병독적감염상황，위림상비인암적조기진단제공의거。방법선취2011-2012년재본원진행건강체검적8550례건강체검자작위관찰조，이동기입원치료적300례비인암환자작위대조조，채용매련면역흡부시험(ELISA)검측병비교량조환자EB병독항체적양성정황。결과(1)관찰조환자공검사출EB-VCA-IgA양성324례，양성솔위3.79%，EB-NA1-IgA양성140례，양성솔위1.64%，EB-EA-IgG양성150례，양성솔위1.75%；상술삼항지표균명현저우대조조，차이유통계학의의(P<0.05)；(2) EB-VCA-IgA、EB-NA1-IgA화EB-EA-IgG적양성정황균여비인암적발생정정상관관계，차우세비OR치분별위7.875、4.998、4.823。결론본지구건강체검인군EB-VCA-IgA적양성솔최고，EB-EA-IgG양성솔차지，EB-NA1-IgA양성솔최저，차EB-VCA-IgA양성환자발생비인암적풍험경고，대EB병독항체진행검측구유중요적림상의의。
Objective To investigate the prevalence of EB virus infection in healthy people in Zhaoqing city and provide evidence for early diagnosis of nasopharyngeal carcinoma. Methods A total of 8 550 people underwent health examination were selected as observation group. And 300 nasopharyngeal carcinoma patients were enrolled as control group. EB antibodies in the two groups were detected by ELISA and then compared. Results (1) In the obser-vation group, the positive rates of EB-VCA-IgA, EB-NA1-IgA and EB-EA-IgG were 3.79%(324 cases), 1.64%(140 cases) and 1.75%(150 cases) respectively, which were all significantly lower than those in the control group (P<0.05);(2) EB-VCA-IgA, EB-NA1-IgA and EB-EA-IgG were positively correlated with nasopharyngeal carcinoma, where OR values were 7.875, 4.998, and 4.823 respectively. Conclusion The positive rate of EB-VCA-IgA in healthy peo-ple in this area is the highest, followed by the positive rate of EB-EA-IgG, and the positive rate of EB-NA1-IgA is the lowest. Patients with positive EB-VCA-IgA have a higher risk of nasopharyngeal carcinoma, therefore it's important for detecting EB antibody.
