CAJ | 학술논문

目的：探讨老年抑郁患者的血浆肾素、血管紧张素Ⅱ、醛固酮(RAAS)含量的变化与抑郁的相关性。方法从2011年开始来我院进行治疗的确诊老年抑郁患者中抽取34例抑郁患者并应用黛力新对其治疗。分别于治疗前、后采用放射免疫法及化学发光法对其进行血浆肾素、血管紧张素Ⅱ及醛固酮含量的测定。从开始治疗到治疗结束每隔2周对患者的抑郁程度进行1次评定，评定量表选用汉密尔顿焦虑量表(HAMA)和汉密尔顿抑郁量表(HAMD)。结果治疗后患者的血管紧张素Ⅱ含量为(174.01±131.19) pg/ml，明显低于治疗前的(435.82±232.80) pg/ml，两者比较差异具有统计学意义(P<0.05)。但治疗前后的血浆肾素分别为(1.64±0.89) ng/ml与(1.20±0.81) ng/ml，治疗前后的血浆醛固酮分别为(0.22±0.07) mmol/L与(0.22±0.08) mmol/L，两者治疗前后的含量变化不明显，差异无统计学意义(P>0.05)。治疗前后患者血管紧张素Ⅱ水平的变化与HAMA和HAMD的减分率间的相关系数分别的-0.429与-0.465，其相关关系为负相关，但血浆肾素与血浆醛固酮水平的变化却与HAMA和HAMD减分率间无明显的相关性。结论老年抑郁患者的血浆肾素、血管紧张素Ⅱ以及醛固酮水平之间存在着一定相关关系，且其血管紧张素Ⅱ水平变化与抑郁密切相关。
목적：탐토노년억욱환자적혈장신소、혈관긴장소Ⅱ、철고동(RAAS)함량적변화여억욱적상관성。방법종2011년개시래아원진행치료적학진노년억욱환자중추취34례억욱환자병응용대력신대기치료。분별우치료전、후채용방사면역법급화학발광법대기진행혈장신소、혈관긴장소Ⅱ급철고동함량적측정。종개시치료도치료결속매격2주대환자적억욱정도진행1차평정，평정량표선용한밀이돈초필량표(HAMA)화한밀이돈억욱량표(HAMD)。결과치료후환자적혈관긴장소Ⅱ함량위(174.01±131.19) pg/ml，명현저우치료전적(435.82±232.80) pg/ml，량자비교차이구유통계학의의(P<0.05)。단치료전후적혈장신소분별위(1.64±0.89) ng/ml여(1.20±0.81) ng/ml，치료전후적혈장철고동분별위(0.22±0.07) mmol/L여(0.22±0.08) mmol/L，량자치료전후적함량변화불명현，차이무통계학의의(P>0.05)。치료전후환자혈관긴장소Ⅱ수평적변화여HAMA화HAMD적감분솔간적상관계수분별적-0.429여-0.465，기상관관계위부상관，단혈장신소여혈장철고동수평적변화각여HAMA화HAMD감분솔간무명현적상관성。결론노년억욱환자적혈장신소、혈관긴장소Ⅱ이급철고동수평지간존재착일정상관관계，차기혈관긴장소Ⅱ수평변화여억욱밀절상관。
Objective To explore the correlation between the change of renin-angiotensin Ⅱ-aldosterone level and elderly depression. Methods Thirty-four patients diagnosed as elderly depression treated with deanxit in our hospital from 2011 were selected. The plasma renin-angiotensinⅡ-aldosterone levels of these patients were mea-sured before and after the treatment by radioimmunoassay and chemiluminescence. The depression degrees in patients were assessed by Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) every two weeks from the start of the treatment to the end of the treatment. Results The angiotensin Ⅱ levels of these patients was (174.01±131.19) pg/ml after the treatment, which was significantly lower than (435.82±232.80) pg/ml before the treat-ment. The levels of plasma renin before and after the treatment were (1.64±0.89) ng/ml and (1.20±0.81) ng/ml respec-tively, and the levels of aldosterone before and after the treatment were (0.22±0.07) mmol/L and (0.22±0.08) mmol/L respectively. The changes of plasma renin and aldosterone levels before and after the treatment were of no statistically significance. The correlation index between the changes of angiotensinⅡlevels before and after the treatment and the reduced rate of HAMA and HAMD was-0.429 and -0.465, which was negatively correlated. However, there were no significant difference between the changes of plasma renin and aldosterone levels before and after the treatment and the reduced rate of HAMA and HAMD. Conclusion There are correlations between plasma renin, angiotensin Ⅱand aldosterone levels in elderly depression patients, and the change of angiotensinⅡlevel is closely related to de-pression.