CAJ | 학술논문

目的：通过家兔单肺通气（OLV）模型，评价静脉注射氨溴索对家兔 OLV 时肺内炎性因子的影响。方法健康家兔30只，采用随机数字表法分为3组（每组10只）：双肺通气组（C 组）、单肺通气组（OLV 组）、静脉注射氨溴索组（A 组）。 C 组行双肺通气2 h ，其余2组行右侧肺通气2 h 。 A 组在右肺通气前10 min 静脉注射氨溴索15 mg /kg 。比较各组通气后右肺支气管肺泡灌洗液中肿瘤坏死因子（TNF）-α、白细胞介素（IL）-1β、IL-8、IL-10浓度的变化，并行组织病理形态学检查。结果与 C 组比较，其余2组右肺灌洗液 TNF-α、IL-1β、IL-8浓度明显升高，IL-10浓度明显降低（ P ＜0．01）。与 OLV 组比较：A 组右肺灌洗液 TNF-α、IL-1β、IL-8浓度明显降低，IL-10浓度明显升高（ P ＜0．01）。与 C 组比较，其余2组病理形态学肺损伤评分明显升高（ P ＜0．01）。与OLV 组比较，A 组肺损伤评分明显降低（ P ＜0．01）。结论静脉注射氨溴索，可有效抑制家兔 OLV 肺内炎性反应。
목적：통과가토단폐통기（OLV）모형，평개정맥주사안추색대가토 OLV 시폐내염성인자적영향。방법건강가토30지，채용수궤수자표법분위3조（매조10지）：쌍폐통기조（C 조）、단폐통기조（OLV 조）、정맥주사안추색조（A 조）。 C 조행쌍폐통기2 h ，기여2조행우측폐통기2 h 。 A 조재우폐통기전10 min 정맥주사안추색15 mg /kg 。비교각조통기후우폐지기관폐포관세액중종류배사인자（TNF）-α、백세포개소（IL）-1β、IL-8、IL-10농도적변화，병행조직병리형태학검사。결과여 C 조비교，기여2조우폐관세액 TNF-α、IL-1β、IL-8농도명현승고，IL-10농도명현강저（ P ＜0．01）。여 OLV 조비교：A 조우폐관세액 TNF-α、IL-1β、IL-8농도명현강저，IL-10농도명현승고（ P ＜0．01）。여 C 조비교，기여2조병리형태학폐손상평분명현승고（ P ＜0．01）。여OLV 조비교，A 조폐손상평분명현강저（ P ＜0．01）。결론정맥주사안추색，가유효억제가토 OLV 폐내염성반응。
Objective To investigate the effects of intravenousinjection (IV ) ambroxol on the inflammatory factors to one lung ventilation (OLV) in rabbit models.Methods Thirty healthy rabbits were randomly divided in-to 3 groups ( n = 10 each) .Control group (group C) received two-lung ventilation for two hours ;group OLV re-ceived right-lung ventilation for two hours ;group A received IV ambroxol 15 mg/kg before right IV ambroxol can inhibit the inflammatory response to OLV in rabbit .Lung ventilation for two hours .Right tracheal fluid concentra-tions of TNF-α ,IL-1β ,IL-8 and IL-10 were determined and light microscopic evaluations were performed to get the lung injury score. Results Right tracheal fluid TNF-α ,IL-1β and IL-8 concentrations were significantly in-creased while IL-10 concentration was significantly decreased as compared with group C in all 3 groups .Right tra-cheal fluid TNF-α ,IL-1β and IL-8 concentrations were significantly lower while IL-10 concentration was signifi-cantly higher in groups A than in group OLV .Lung injury scores were significantly lower at right lung in group A than in group OLV .Conclusion IV ambroxol can inhibit the inflammatory response to OLV in rabbit .