CAJ | 학술논문

树突状细胞(DC)是目前已知体内功能最强的抗原递呈细胞。细胞因子诱导的杀伤(CIK)细胞是一种高效、广谱杀瘤活性的非主要组织相容性复合体限制性免疫效应细胞。DC细胞与CIK细胞的有机结合可产生特异性免疫和非特异性免疫的双重抗肿瘤作用。DC-CIK合理应用可有效提高机体抗肿瘤作用，能够杀伤清除不能用手术切除的极微小瘤灶或体内散存的肿瘤细胞，起到延缓或阻止肿瘤转移或复发的作用，为肾癌治疗开辟了一条新的治疗途径。现就DC-CIK治疗肾癌的研究进展予以综述。
수돌상세포(DC)시목전이지체내공능최강적항원체정세포。세포인자유도적살상(CIK)세포시일충고효、엄보살류활성적비주요조직상용성복합체한제성면역효응세포。DC세포여CIK세포적유궤결합가산생특이성면역화비특이성면역적쌍중항종류작용。DC-CIK합리응용가유효제고궤체항종류작용，능구살상청제불능용수술절제적겁미소류조혹체내산존적종류세포，기도연완혹조지종류전이혹복발적작용，위신암치료개벽료일조신적치료도경。현취DC-CIK치료신암적연구진전여이종술。
Dendritic cells (DC) are known as the most potent antigen-presenting cells (APC). Cytokine in-duced killer (CIK) cells have highly anti-tumor activity and are a kind of highly efficient, broad-spectrum killing tu-mor cells with non-MHC-restriction. The combination of DC and CIK can provide both specific-immune and nonspe-cific-immune anti-tumor functions. The reasonable application of DC-CIK can effectively improve the anti-tumor ef-fect of human body. It can kill tiny tumor cells which spread in the body and cannot be removed by surgery. It de-creased and prevented tumor metastasis and recurrence, which provides a new strategy for renal carcinoma treatment.