CAJ | 학술논문

目的：观察长期服用银杏叶片治疗突发性耳聋的临床效果。方法将60例突发性耳聋患者随机分为对照组和治疗组，每组30例。两组患者均接受口服泼尼松加前列地尔静脉滴注等常规治疗14 d；治疗组在常规治疗基础上加用口服银杏叶片治疗1年，一次1片，3次/d。分别于开始治疗、治疗第14天、治疗第3个月及治疗后1年评估相关症状及复查电测听。结果治疗第14天两组患者无论听力或者耳鸣等症状，组间差异均无统计学意义(P>0.05)；治疗后3个月及治疗后1年听力疗效方面，治疗组有效率分别为76.7%(23/30)及83.3%(25/30)；对照组有效率分别为50.0%(15/30)及60.0%(18/30)，差异均有统计学意义(P<0.05)。治疗后1年，35例伴发耳鸣者，治疗组耳鸣改善率为66.7%(12/18)，对照组改善率为29.4%(5/17)，差异有统计学意义(P<0.05)。结论长期口服银杏叶片治疗突发性耳聋方法简便，具有确切的远期疗效，用药安全，值得临床推广。
목적：관찰장기복용은행협편치료돌발성이롱적림상효과。방법장60례돌발성이롱환자수궤분위대조조화치료조，매조30례。량조환자균접수구복발니송가전렬지이정맥적주등상규치료14 d；치료조재상규치료기출상가용구복은행협편치료1년，일차1편，3차/d。분별우개시치료、치료제14천、치료제3개월급치료후1년평고상관증상급복사전측은。결과치료제14천량조환자무론은력혹자이명등증상，조간차이균무통계학의의(P>0.05)；치료후3개월급치료후1년은력료효방면，치료조유효솔분별위76.7%(23/30)급83.3%(25/30)；대조조유효솔분별위50.0%(15/30)급60.0%(18/30)，차이균유통계학의의(P<0.05)。치료후1년，35례반발이명자，치료조이명개선솔위66.7%(12/18)，대조조개선솔위29.4%(5/17)，차이유통계학의의(P<0.05)。결론장기구복은행협편치료돌발성이롱방법간편，구유학절적원기료효，용약안전，치득림상추엄。
Objective To observe the long-term effect of the treatment for sudden deafness with long-term use of ginkgo biloba extract. Methods Sixty patients of sudden deafness were divided into the control group (30 cas-es) and the treatment group (30 cases) in random. The two groups were all given prednisone and alprostadil by intrave-nous infusion simultaneously, and the treatment group was given one-year use of ginkgo biloba extract additionally, one piece per time, 3 times per day. Audiometry and symptoms were tested and evaluated at the beginning of treat-ment, 14 days, 3 months and one year after treatment. Results After 14 days of treatment, there was no statistically significant difference between the two groups in hearing and tinnitus (P>0.05). Three months, one year after treat-ment, the effective rate in treatment group was 76.7%(23/3) and 83.3%(25/30), significantly higher than 50.0%(15/30) and 60.0%(18/30) in the control group (P<0.05). One year after treatment, 35 patients had concomitant symptoms of tinnitus (17 cases of the control group and 18 cases of the treatment group), and the improvement rate of tinnitus [66.7% (12/18)] in treatment group was significantly higher than that in the control group [29.4% (5/17)], P<0.05. Conclusion Long-term use of ginkgo biloba extract can improve the long-term clinical efficacy in patients with sud-den deafness, which is worthy of clinical promotion.