CAJ | 학술논문

BACKGROUND:?Portal? vein? embolization? not? only? induces?hypertrophy? of? the? non-embolized? liver,? but? also? enhances?tumor?growth.?The?latter?could?be?prevented?by?embolizing?the?hepatic? arteries? supplying? the? tumor-bearing? liver? segments.?This? study? aimed? to? determine? the? effects? of? transcatheter?arterial? embolization? (TAE)? on? tumor? volume? and? liver?regeneration?in?a?rabbit?VX2?tumor?model. <br> METHODS:?Twenty-three? rabbits? underwent? subcapsular?tumor? implantation? with? a? VX2? tumor.? Two? weeks? after?implantation,? 18? rabbits? were? used? for? TAE? experiments,? 5?were?for?sham?controls.?Tumor?response?and?liver?regeneration?response?of?the? embolized? cranial? and? non-embolized?caudal?liver?lobes?were?assessed?by?CT?volumetry,?liver?to?body?weight?index,?and?the?amount?of?proliferating?hepatocytes. <br> RESULTS:?All? super-selective? arterial? tumor? embolization?procedures?were?performed?successfully.?Despite?embolization,?the? tumor? volume? increased? after? an? initial? steady? state.? The?tumor?volume?after?embolization?was?smaller?than?that?of?the?sham? group,? but? this? difference? was? not? significant.? Massive?necrosis? of? the? tumor,? however,? was? seen? after? embolization,?without? damage? of? the? surrounding? liver? parenchyma.? There?was?a?significant?atrophy?response?of?the?tumor?bearing?cranial?lobe? after? super-selective? arterial? embolization? of? the? tumor?with?a?concomitant?hypertrophy?response?of?the?non-embolized,?caudal? lobe.? This? regeneration? response? was? confirmed?histologically?by?a?significantly?higher?number?of?proliferating?hepatocytes?on?the?Ki-67?stained?slides. <br> CONCLUSIONS:?Super-selective,?bland?arterial?coil?embolization?causes?massive?necrosis?of?the?tumor,?despite?increase?of?volume?on? CT? scan.? Atrophy? of? the? tumor? bearing? liver? lobe? is? seen?after? arterial? embolization? of? the? tumor? with? a? concomitant?hypertrophy? response? of? the? non-embolized? lobe,? despite?absence?of?histological?damage?of?the?tumor-surrounding?liver?parenchyma.