CAJ | 학술논문

BACKGROUND:?Non-alcoholic?fatty?liver?disease?(NAFLD)?is?a?leading?cause?of?chronic?liver?injury?and?mortality?in?Western?countries? and? China.? However,? as? to? date,? there? is? no? direct?and? effective? therapy? for? this? disease.? The? aim? of? this? review?is?to?analyze?the?key?progress?and?challenges?of?main?current?therapeutic?approaches?in?NAFLD. <br> DATA? SOURCE:??We?carried?out?a?PubMed?search?of?English-language?articles?relevant?to?NAFLD?therapy. <br> RESULTS:?There? are? two? major? therapeutic? strategies? for?NAFLD? treatment:? (1)? lifestyle? interventions? (including?weight? reduction,? dietary? modification? and? physical? exercise)?and? (2)? pharmaceutical? therapies.? Lifestyle? interventions,?particularly? chronic? and? moderate? intensity? exercise,? are? the?most? effective? and? recognized? clinical? therapies? for? NAFLD.?For? pharmaceutical? therapies,? although? their? effects? and?mechanisms? have? been? extensively? investigated? in? laboratory?studies,?they?still?need?further?tests?and?investigations?in?clinical?human?trials. <br> CONCLUSION:?Future? advancement? of? NAFLD? therapy?should? focus? on? the? mechanistic? studies? on? cell? based? and?animal?models?and?human?clinical?trials?of?exercise,?as?well?as?the? combination? of? lifestyle? intervention? and? pharmaceutical?therapy?specifically?targeting?main?signaling?pathways?related?to?lipid?metabolism,?oxidative?stress?and?inflammation.