CAJ | 학술논문

BACKGROUND:?Early? detection? of? graft? malfunction? or?postoperative? complications? is? essential? to? save? patients? and?organs?after?orthotopic?liver?transplantation?(OLT).?Predictive?tests? for? graft? dysfunction? are? needed? to? enable? earlier?implementation? of? organ-saving? interventions? following?transplantation.?This?study?was?undertaken?to?assess?the?value?of?indocyanine?green?plasma?disappearance?rates?(ICG-PDRs)?for?predicting?postoperative?complications,?graft?dysfunction,?and?patient?survival?following?OLT. <br> METHODS:?Eighty-six?patients?undergoing?OLT?were?included?in?this?single-centre?trial.?ICG-PDR?was?assessed?daily?for?the?first?7?days?following?OLT.?Endpoints?were?graft?loss?or?death?within?30?days?and?postoperative?complications,?graft?loss,?or?death?within?30?days. <br> RESULTS:?Postoperative?complications?of?31?patients?included?deaths?(12?patients)?or?graft?losses.?ICG-PDR?was?significantly?different?in?patients?whose?endpoints?were?graft?loss?or?death?beginning?from?day?3?and?in?those?whose?endpoints?were?graft-loss,? death,? or? postoperative? complications? beginning? from?day? 4? after? OLT.? For? day? 7? measurements,? receiver? operating?characteristic? curve? analysis? revealed? an? ICG-PDR? cut-off? for?predicting? death? or? graft? loss? of? 9.6%? per? min? (a? sensitivity?of?75.0%,?a?specificity?of?72.6%,?positive?predictive?value?0.35,?negative?predictive?value?0.94).?For?prediction?of?graft?loss,?death,?or?postoperative?complications,?the?ICG-PDR?cut-off?was?12.3%?per?min?(a?sensitivity?of?68.9%,?a?specificity?of?66.7%,?positive?predictive?value? 0.57,?negative?predictive?value?0.77). <br> CONCLUSIONS:?ICG-PDR? measurements? on? postoperative?day?7?are?predictive?of?early?patient?outcomes?following?OLT.?The?added?value?over?that?of?routinely?determined?laboratory?parameters?is?low.