CAJ | 학술논문

BACKGROUND:?Although?low?central?venous?pressure?(CVP)?has? been? used? to? minimize? blood? loss? during? hepatectomy,?the? impact? of? variations? of? CVP? on? the? rate? of? blood? loss?and?on?the?perfusion?of?end-organs?has?not?been?evaluated.?This? animal? study? aimed? to? evaluate? the? hemodynamics?and? oxygen? transport? changes? during? hepatic? resection? at?different?CVP?levels. <br> METHODS:?Forty-eight? anesthetized? Bama? miniature? pigs?were?divided?into?8?groups?with?CVP?during?hepatic?resection?controlled?at?0?to?<1,?1?to?<2,?2?to?<3,?3?to?<4,?4?to?<5,?5?to?<6,?6?to?<7,?and?7?to?<8?cmH2O.?Intergroup?comparisons?were?made?for?hemodynamic?parameters,?oxygen?transport?dynamics,?and?the?rate?of?blood?loss. <br> RESULTS:?The? rate? of? blood? loss? and? the? hepatic? venous?pressure?during?hepatic?resection?were?almost?linearly?related?to? the? CVP.? A? significant? drop? in? the? mean? arterial? pressure,?cardiac?output,?and?cardiac?index?occurred?between?CVP?≥2?and?<2?cmH2O.?Oxygen?delivery?(DO2),?oxygen?consumption?(VO2)?and?oxygen?extraction?ratio?(ERO2)?remained?relatively?constant?between?CVPs?of?2?to?<8?cmH2O.?There?was?a?significant?drop?in?DO2?when?the?CVP?was?<2?cmH2O.?There?was?also?a?significant?drop?in?VO2?and?ExO2?when?the?CVP?was?<1?cmH2O. <br> CONCLUSION:?The??optimal??CVP??for?hepatic?resection?is?2?to?3?cmH2O.