CAJ | 학술논문

目的：探讨基质金属蛋白酶‐9（MMP‐9）、白细胞介素‐6（IL‐6）和白细胞介素‐10（IL‐10）与脑动脉粥样硬化斑块不稳定性以及脑梗死的关系。方法选择急性脑血管病患者56例，其中反复短暂性脑缺血发作（TIA）16例，急性脑梗死40例。对照组为21例健康体检者。所有缺血性脑血管病患者均经头CT血管造影（CTA）检查或颈部血管超声证实存在不稳定斑块，且发病机制考虑与不稳定斑块破裂有关。采用ELISA方法检测各组血清MMP‐9、IL‐6和IL‐10水平并进行比较。结果急性脑梗死组患者血清中MMP‐9、IL‐10水平分别为（137.10±69.38）ng/mL和（39.16±32.82）pg/mL，TIA组患者血清中MMP‐9、IL‐10水平分别为（119.79±65.54）ng/mL和（33.00±21.36）pg/mL，均明显高于对照组〔分别为（65.42±36.81）ng/mL和（19.83±12.16）pg/mL〕；脑梗死组患者血清MMP‐9及IL‐10水平均高于TIA组（均P＜0.05）。各组间IL‐6水平差异无统计学意义（均P＞0.05）。结论MMP‐9和IL‐10水平升高可能与动脉粥样硬化不稳定斑块破裂以及脑梗死灶形成有关。
목적：탐토기질금속단백매‐9（MMP‐9）、백세포개소‐6（IL‐6）화백세포개소‐10（IL‐10）여뇌동맥죽양경화반괴불은정성이급뇌경사적관계。방법선택급성뇌혈관병환자56례，기중반복단잠성뇌결혈발작（TIA）16례，급성뇌경사40례。대조조위21례건강체검자。소유결혈성뇌혈관병환자균경두CT혈관조영（CTA）검사혹경부혈관초성증실존재불은정반괴，차발병궤제고필여불은정반괴파렬유관。채용ELISA방법검측각조혈청MMP‐9、IL‐6화IL‐10수평병진행비교。결과급성뇌경사조환자혈청중MMP‐9、IL‐10수평분별위（137.10±69.38）ng/mL화（39.16±32.82）pg/mL，TIA조환자혈청중MMP‐9、IL‐10수평분별위（119.79±65.54）ng/mL화（33.00±21.36）pg/mL，균명현고우대조조〔분별위（65.42±36.81）ng/mL화（19.83±12.16）pg/mL〕；뇌경사조환자혈청MMP‐9급IL‐10수평균고우TIA조（균P＜0.05）。각조간IL‐6수평차이무통계학의의（균P＞0.05）。결론MMP‐9화IL‐10수평승고가능여동맥죽양경화불은정반괴파렬이급뇌경사조형성유관。
Objective To investigate the relationship between matrix metalloproteinase‐9 (MMP‐9) , interleukin‐6 (IL‐6 ) , interleukin‐10 (IL‐10 ) and the stability of cerebral atherosclerotic plaque and cerebral infarction .Methods Serum of 56 patients with acute cerebral vascular diseases (including 16 repeated transient ischemic attack (TIA) and 40 acute cerebral infarction (ACI)) ,were collected within 3 days of onset ,all the patients were given examinations such as computed tomography angiography (CTA) or Doppler ultrasonography or magnetic resonance angiography (MRA ) to investigate if there was unstable plaque . The control group includes 21 healthy volunteers .The levels of serum MMP‐9 ,IL‐6 and IL‐10 were detected using enzyme‐linked immunosorbent assay (ELISA) in all the subjects .Results Patients with ACI and TIA had higher serum levels of MMP‐9 [(137.10 ± 69.38) ng/mL and (119.79 ± 65.54) ng/mL vs. (65.42 ± 36.81) ng/mL , P<0.05] and IL‐10 [ (39.16 ± 32.82) pg/mL and (33.00 ± 21.36) pg/mL vs. (19.83 ± 12.16) pg/mL , P< 0.05] than controls ,there were also significant difference between the group ACI and TIA (P<0.05) .But there was no significant difference between groups in IL‐6 level (P>0.05) .Conclusions MMP‐9 and IL‐10 levels rise in the acute period of ACI and TIA ,suggesting that it may be related with the rupture of unstable plaque .