包头医学院学报
包頭醫學院學報
포두의학원학보
JOURNAL OF BAOTOU MEDICAL COLLEGE
2014年
5期
42-44
,共3页
刘肖瑛%冯志刚%徐名烤%修宁宁
劉肖瑛%馮誌剛%徐名烤%脩寧寧
류초영%풍지강%서명고%수저저
系统性红斑狼疮%干燥综合征%自身抗体
繫統性紅斑狼瘡%榦燥綜閤徵%自身抗體
계통성홍반랑창%간조종합정%자신항체
Systemic lupus erythematosus%Sjogren's syndrome%Autoimmune antibody
目的：探讨系统性红斑狼疮合并干燥综合征患者血清自身抗体检测的临床意义。方法：用免疫荧光法和免疫印迹法测定123例 SLE、13例 SLE - SS、111例 pSS 患者血清 ANA 和 SSARo60kD、SSB、Sm、dsDNA、Ro -52等自身抗体，应用 SPSS 14.0对检测结果进行卡方检验。结果：SLE、SLE - SS、pSS 患者 ANA 阳性率分别为67.5%、61.5%、42.3%，SSARo60kD 阳性率分别为27.6%、76.9%、64.9%，SSB 阳性率分别为10.6%、38.5%、36.0%，Sm 阳性率分别为21.1%、23.1%、0.9%，dsDNA 阳性率分别为53.7%、53.8%、1.8%，Ro -52阳性率分别为7.3%、30.8%、26.1%。ANA、dsDNA、Sm 在 SLE、SLE - SS 患者组阳性率显著高于 pSS 组，SSARo60kD、SSB、Ro -52抗体 SLE - SS、pSS患者组显著高于 SLE 组。结论：联合使用多种自身抗体对 SLE 合并 SS 患者具有鉴别诊断意义。
目的：探討繫統性紅斑狼瘡閤併榦燥綜閤徵患者血清自身抗體檢測的臨床意義。方法：用免疫熒光法和免疫印跡法測定123例 SLE、13例 SLE - SS、111例 pSS 患者血清 ANA 和 SSARo60kD、SSB、Sm、dsDNA、Ro -52等自身抗體，應用 SPSS 14.0對檢測結果進行卡方檢驗。結果：SLE、SLE - SS、pSS 患者 ANA 暘性率分彆為67.5%、61.5%、42.3%，SSARo60kD 暘性率分彆為27.6%、76.9%、64.9%，SSB 暘性率分彆為10.6%、38.5%、36.0%，Sm 暘性率分彆為21.1%、23.1%、0.9%，dsDNA 暘性率分彆為53.7%、53.8%、1.8%，Ro -52暘性率分彆為7.3%、30.8%、26.1%。ANA、dsDNA、Sm 在 SLE、SLE - SS 患者組暘性率顯著高于 pSS 組，SSARo60kD、SSB、Ro -52抗體 SLE - SS、pSS患者組顯著高于 SLE 組。結論：聯閤使用多種自身抗體對 SLE 閤併 SS 患者具有鑒彆診斷意義。
목적：탐토계통성홍반랑창합병간조종합정환자혈청자신항체검측적림상의의。방법：용면역형광법화면역인적법측정123례 SLE、13례 SLE - SS、111례 pSS 환자혈청 ANA 화 SSARo60kD、SSB、Sm、dsDNA、Ro -52등자신항체，응용 SPSS 14.0대검측결과진행잡방검험。결과：SLE、SLE - SS、pSS 환자 ANA 양성솔분별위67.5%、61.5%、42.3%，SSARo60kD 양성솔분별위27.6%、76.9%、64.9%，SSB 양성솔분별위10.6%、38.5%、36.0%，Sm 양성솔분별위21.1%、23.1%、0.9%，dsDNA 양성솔분별위53.7%、53.8%、1.8%，Ro -52양성솔분별위7.3%、30.8%、26.1%。ANA、dsDNA、Sm 재 SLE、SLE - SS 환자조양성솔현저고우 pSS 조，SSARo60kD、SSB、Ro -52항체 SLE - SS、pSS환자조현저고우 SLE 조。결론：연합사용다충자신항체대 SLE 합병 SS 환자구유감별진단의의。
Objective:To investigate the clinical significance of the detection of serum autoimmune antibodies in Systemic Lupus Erythematosus( SLE)patients complicated with Sjogrenˊs Syndrome( SS). Methods:Such autoimmune antibodies as ANA,SSARo60kD,SS - B,Sm,dsDNA and Ro - 52 in 123 SLE patients,13 SLE - SS patients and 111 pSS patients were deter-mined by immunofluorescence and immunoblot assay,with the detection results analyzed by SPSS 14. 0. Results:ANA positive rate in SLE,SLE - SS and SS patients was 67. 5 % ,61. 5 % and 42. 3 % ;SSARo60kD positive rate 27. 6 % ,76. 9 % and 64. 9 % ;SS - B positive rate 10. 6 % ,38. 5% and 36. 0 % ;Sm positive rate 21. 1% ,23. 1% and 0. 9% ;dsDNA positive rate 53. 7% ,53. 8% and 1. 8% ;Ro - 52 positive rate 7. 3 % ,30. 8 % and 26. 1 % . The positive rate of ANA,ds - DNA and Sm in SLE and SLE - SS patients was significantly higher than that in pSS patients. The positive rate of SSARo60kD,SS - B and Ro - 52 in SLE - SS and pSS patients was higher than that in SLE patients. Conclusion:The combination of several autoimmune antibodies is of differential significance for patients with SLE - SS.
