CAJ | 학술논문

目的：研究人附睾分泌蛋白4（ HE4）在卵巢良性、交界性和恶性上皮性肿瘤的表达，探讨HE4在卵巢癌发生发展及诊断中的作用。方法：应用免疫组化EnVision法检测20例卵巢良性上皮性肿瘤、15例交界性肿瘤和55例恶性上皮性肿瘤中HE4表达。结果：HE4在卵巢良性、交界性和恶性上皮性肿瘤中的阳性表达率分别为15.5％、53.3％和83.6％，HE4在卵巢恶性上皮性肿瘤中的表达明显高于卵巢交界性和良性上皮性肿瘤，差异有统计学意义（P＜0.05，P＜0.01）。随着临床分期增高，HE4蛋白阳性表达率亦逐渐增高，但无统计学意义（ P＞0.05）；HE4蛋白表达与卵巢癌淋巴结转移无相关性（ P＞0.05）。HE4主要在卵巢浆液性肿瘤和子宫内膜样癌中表达。结论：HE4在卵巢恶性上皮性肿瘤中高表达提示其可能作为诊断卵巢癌的一种标记物，且肿瘤组织学类型可能为浆液性肿瘤和子宫内膜样癌。
목적：연구인부고분비단백4（ HE4）재란소량성、교계성화악성상피성종류적표체，탐토HE4재란소암발생발전급진단중적작용。방법：응용면역조화EnVision법검측20례란소량성상피성종류、15례교계성종류화55례악성상피성종류중HE4표체。결과：HE4재란소량성、교계성화악성상피성종류중적양성표체솔분별위15.5％、53.3％화83.6％，HE4재란소악성상피성종류중적표체명현고우란소교계성화량성상피성종류，차이유통계학의의（P＜0.05，P＜0.01）。수착림상분기증고，HE4단백양성표체솔역축점증고，단무통계학의의（ P＞0.05）；HE4단백표체여란소암림파결전이무상관성（ P＞0.05）。HE4주요재란소장액성종류화자궁내막양암중표체。결론：HE4재란소악성상피성종류중고표체제시기가능작위진단란소암적일충표기물，차종류조직학류형가능위장액성종류화자궁내막양암。
Objective:To investigate the expression of human epididymis protein 4 (HE4) in benign,borderline and malignant epithelial tumor of ovary, and its role in the carcinogenesis and progression as well as diagnosis of ovarian cancer.Methods:Immunohistochemical EnVision technique was used to detect the expression of HE4 in 20 cases of benign tumor,15 borderline tumor and 55 malignancies.Results:HE4 was positively expressed in 15.5% of benign tumors,53.3% in borderline and 83.6% in malignancies,respectively.HE4 expression was higher in ovarian malignant epithelial tumor than in borderline and benign epithelial cases,which suggested statistical difference(P<0.05,P<0.01).Although HE4 expression was increased with advanced clinical stage,yet it had no statistical significance and no correlation with lymph node metastasis (P>0.05).Expression of HE4 was predominantly seen in serous tumor and endometrioid adenocarcinoma .Conclusion:High expression of HE4 in ovarian cancer can be a novel biomarker for diagnosis of ovarian malignant epithelial cancer,this histological marker may be suggestive of serous tumor and endometrioid adenocarcinoma .