包头医学院学报
包頭醫學院學報
포두의학원학보
JOURNAL OF BAOTOU MEDICAL COLLEGE
2014年
5期
39-41
,共3页
原发性干燥综合征%肾结石%肾钙化
原髮性榦燥綜閤徵%腎結石%腎鈣化
원발성간조종합정%신결석%신개화
Primary Sjogrenˊs syndrome%Kidney stones%Nephrocalcinosis
目的：肾钙化或肾结石是原发性干燥综合征（pSS）患者少见的并发症，通过分析 pSS 患者合并肾钙化或肾结石的临床资料并查阅相关文献以提高对本病的认识。方法：对1998年1月至2012年12月期间包头医学院第一附属医院明确诊断为 pSS 合并肾钙化或肾结石的25例住院患者临床资料进行回顾性分析，包括临床表现、实验室检查、治疗及预后。结果：年龄（42.8±7.7）岁，其中男1例，女24例。8例行骨密度检查，其中6例提示骨量流失或骨质疏松。25例患者中，11例患者单用激素治疗，10例患者给予激素及免疫抑制剂治疗，4例仅给予对症治疗。结论：原发性干燥综合征并肾钙化或肾结石的发生与发病初期疾病活动度、病程长短及确诊 pSS 后是否规律治疗等因素相关，激素及免疫抑制剂治疗可以抑制肾脏钙化及肾结石的进展。
目的：腎鈣化或腎結石是原髮性榦燥綜閤徵（pSS）患者少見的併髮癥，通過分析 pSS 患者閤併腎鈣化或腎結石的臨床資料併查閱相關文獻以提高對本病的認識。方法：對1998年1月至2012年12月期間包頭醫學院第一附屬醫院明確診斷為 pSS 閤併腎鈣化或腎結石的25例住院患者臨床資料進行迴顧性分析，包括臨床錶現、實驗室檢查、治療及預後。結果：年齡（42.8±7.7）歲，其中男1例，女24例。8例行骨密度檢查，其中6例提示骨量流失或骨質疏鬆。25例患者中，11例患者單用激素治療，10例患者給予激素及免疫抑製劑治療，4例僅給予對癥治療。結論：原髮性榦燥綜閤徵併腎鈣化或腎結石的髮生與髮病初期疾病活動度、病程長短及確診 pSS 後是否規律治療等因素相關，激素及免疫抑製劑治療可以抑製腎髒鈣化及腎結石的進展。
목적：신개화혹신결석시원발성간조종합정（pSS）환자소견적병발증，통과분석 pSS 환자합병신개화혹신결석적림상자료병사열상관문헌이제고대본병적인식。방법：대1998년1월지2012년12월기간포두의학원제일부속의원명학진단위 pSS 합병신개화혹신결석적25례주원환자림상자료진행회고성분석，포괄림상표현、실험실검사、치료급예후。결과：년령（42.8±7.7）세，기중남1례，녀24례。8례행골밀도검사，기중6례제시골량류실혹골질소송。25례환자중，11례환자단용격소치료，10례환자급여격소급면역억제제치료，4례부급여대증치료。결론：원발성간조종합정병신개화혹신결석적발생여발병초기질병활동도、병정장단급학진 pSS 후시부규률치료등인소상관，격소급면역억제제치료가이억제신장개화급신결석적진전。
Objective:To improve the understanding of nephrocalcinosis or kidney stones,a rare complication of primary Sjogrenˊs syndrome(pSS),through analyzing the clinical data of pSS patients with the complication of nephrocalcinosis or kidney stones and systematically reviewing the related medical literature. Methods:The clinical data of 25 pSS patients with the compli-cation of nephrocalcinosis or kidney stones,diagnosed at the First Affiliated Hospital of Baotou Medical College from January 1998 to December 2012,were retrospectively analyzed,involving clinical manifestations,laboratory tests,treatment and progno-sis of the disease. Results:Of 25 patients( aged 42. 8 ± 7. 7,24 females and 1male),loss of bone mass or osteoporosis was ob-served in the 6 of 8 patients whose bone mineral density was tested. Of 25 patients,eleven patients were treated only by cortico-steroids;ten patients were treated by corticosteroids and immunodepressants;four patients were treated according to their symp-toms. Conclusion:The occurrence of nephrocalcinosis or kidney stones complicating primary Sjogrenˊs syndrome is closely relat-ed with the disease activity in the early stages,the course of the disease and the treatment of the disease. Corticosteroids and im-munosuppressive may be effective in controlling the development of nephrocalcinosis and kidney stones.
