皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2014年
5期
393-395
,共3页
人乳头瘤病毒%基因分型%感染%宫颈癌
人乳頭瘤病毒%基因分型%感染%宮頸癌
인유두류병독%기인분형%감염%궁경암
human papillomavirus%genotyping%infection%cervical cancer
目的:了解门诊就诊的高危人群人乳头瘤病毒( HPV)感染情况及分型特点,为该区宫颈癌的防治和HPV疫苗的研发提供参考。方法:回顾性分析2012年1月~2013年12月我院妇科门诊5511例女性宫颈细胞学标本的HPV基因分型检测结果。结果:①5511例受检者中HPV总感染率为17.13%,高危亚型组优势型别依次为16、58、52、33、18、31,低危亚型组依次为11、6、44。②单一、多重感染率分别为13.06%、4.06%,差异有统计学意义(χ2=285.012,P=0.000)。③高危型、低危型、混合感染率分别为16.64%、0.96%、0.36%,差异均有统计学意义(χ2=1667.737,P=0.000)。④~44岁组、45~59岁组、60~岁组的感染率依次为17.98%、13.32%、32.93%,不同年龄段HPV感染率结果差异有统计学意义(χ2=47.102,P=0.000)。结论:门诊高危人群HPV感染率为17.13%,常见型别为16、58、52;60~岁组为感染的高峰人群,应加强此类人群的检测,及早发现宫颈病变及宫颈癌。
目的:瞭解門診就診的高危人群人乳頭瘤病毒( HPV)感染情況及分型特點,為該區宮頸癌的防治和HPV疫苗的研髮提供參攷。方法:迴顧性分析2012年1月~2013年12月我院婦科門診5511例女性宮頸細胞學標本的HPV基因分型檢測結果。結果:①5511例受檢者中HPV總感染率為17.13%,高危亞型組優勢型彆依次為16、58、52、33、18、31,低危亞型組依次為11、6、44。②單一、多重感染率分彆為13.06%、4.06%,差異有統計學意義(χ2=285.012,P=0.000)。③高危型、低危型、混閤感染率分彆為16.64%、0.96%、0.36%,差異均有統計學意義(χ2=1667.737,P=0.000)。④~44歲組、45~59歲組、60~歲組的感染率依次為17.98%、13.32%、32.93%,不同年齡段HPV感染率結果差異有統計學意義(χ2=47.102,P=0.000)。結論:門診高危人群HPV感染率為17.13%,常見型彆為16、58、52;60~歲組為感染的高峰人群,應加彊此類人群的檢測,及早髮現宮頸病變及宮頸癌。
목적:료해문진취진적고위인군인유두류병독( HPV)감염정황급분형특점,위해구궁경암적방치화HPV역묘적연발제공삼고。방법:회고성분석2012년1월~2013년12월아원부과문진5511례녀성궁경세포학표본적HPV기인분형검측결과。결과:①5511례수검자중HPV총감염솔위17.13%,고위아형조우세형별의차위16、58、52、33、18、31,저위아형조의차위11、6、44。②단일、다중감염솔분별위13.06%、4.06%,차이유통계학의의(χ2=285.012,P=0.000)。③고위형、저위형、혼합감염솔분별위16.64%、0.96%、0.36%,차이균유통계학의의(χ2=1667.737,P=0.000)。④~44세조、45~59세조、60~세조적감염솔의차위17.98%、13.32%、32.93%,불동년령단HPV감염솔결과차이유통계학의의(χ2=47.102,P=0.000)。결론:문진고위인군HPV감염솔위17.13%,상견형별위16、58、52;60~세조위감염적고봉인군,응가강차류인군적검측,급조발현궁경병변급궁경암。
Objective:To investigate the infection status and distribution of human papillomavirus ( HPV) genotypes in female outpatients in order to sup-ply evidences for the cervical cancer prevention and HPV vaccine development .Methods:HPV genotyping results were retrospectively summarized in 5 511 women undergone cytological screening of HPV at the outpatient of our hospital between January 2012 and December 2013.Results:①Positive HPV infec-tion was found in 17.13% of the 5 511 women,and the high-risk HPV was associated with genotype 16,58,52,33,18 and 31,and low-risk with 11,6 and 4;②The simple infection(13.06%;720/5 511) and the mixed infection(4.06%;224/5 511) were statistically different(χ2 =285.012,P=0.000);③The positive rate for high-risk,low-risk and mixed infection was 16.64%,0.96% and 0.36%,respectively,with statistical significance(χ2 =1 667.737, P=0.000);④The total HPV infection rate for patients under 44 years of age,between 45 and 59 years,or over 60 years was 17.98%,13.32% and 32.93%,respectively,and the infection rate was significant for different age groups (χ2 =47.102,P =0.000).Conclusion:HPV infection rate was 17.12% in our outpatients,and HPV16,58 and 52 appear more prevalent.Besides,patients over 60 years of age are in highest risks of HPV infection,sug-gesting that this group of population shall be subjected to extensive HPV screening for early prevention of the cervical lesions or cancers .