CAJ | 학술논문

目的运用ICP法分析宫内节育器用铜原材料的体外铜离子释放特性，分析形状及纯度与铜释放量之间的关系。方法将铜原材料按100倍比例稀释浸泡于37.0±0.5℃模拟宫腔液中，定期换液并收集，ICP测定其铜离子浓度。结果单天铜离子的最大释放量均出现在7 d内，99.95%与99.99%的铜丝其铜离子释放量没有明显差异（P >0.05），早期铜丝的铜离子释放量远大于铜管（P<0.01)，第56 d时各组铜释放量趋于稳定。结论 ICP法能有效分析铜离子的释放特性，在相同面积下，铜丝的铜离子释放量比铜管更大。
목적운용ICP법분석궁내절육기용동원재료적체외동리자석방특성，분석형상급순도여동석방량지간적관계。방법장동원재료안100배비례희석침포우37.0±0.5℃모의궁강액중，정기환액병수집，ICP측정기동리자농도。결과단천동리자적최대석방량균출현재7 d내，99.95%여99.99%적동사기동리자석방량몰유명현차이（P >0.05），조기동사적동리자석방량원대우동관（P<0.01)，제56 d시각조동석방량추우은정。결론 ICP법능유효분석동리자적석방특성，재상동면적하，동사적동리자석방량비동관경대。
Objective To study the Cupric ion release characteristics of dif erent copper raw materials in intrauterine device in vitro by ICP. Reveal the relationship between purity and shape of Cu-IUD copper and copper ion release. Methods According to a certain proportion, the copper raw materials were 100 times diluted into the simulated uterine solution at 37± 0.5 oC. Replaced medium at certain time points and col ected soaking liquid. Using ICP analyzed the concentration of copper ion released. Results The largest daily release of copper ions was in the first 7 days. There was no statistical y significant difference between the copper ion release amount of 99.99%and 99.95%purity copper wire ( P>0.05). The release of copper ion of the copper wire was far greater than that of the copper pipe in early stage (P<0.01).The release amount decreased and stabilized at 56 day. Conclusion Release characteristics of copper ion could effectively analysis by ICP. And in the same area, the release amount of copper ions of copper wire was greater than that of copper pipe.