CAJ | 학술논문

目的：观察鹿瓜多肽联用甲氨蝶呤治疗合并骨质疏松的类风湿关节炎患的疗效。方法：72例合并骨质疏松的类风湿关节炎患者随机平分为对照组和治疗组，对照组采用甲氨蝶呤；治疗组采用鹿瓜多肽注射液及甲氨蝶呤，比较两组效果。结果：治疗组总有效率、双腕关节骨密度均显著高于对照组（P<0.05）；治疗后两组患者ESR、RF、CRP水平均显著低于治疗前（P<0.05），且治疗组均低于对照组（P<0.05）；治疗组病情复发率显著低于对照组（P<0.05），两组治疗期间均未见药物不良反应。结论：鹿瓜多肽联合甲氨蝶呤治疗合并骨质疏松症的类风湿关节炎患者具有良好疗效，能显著提高患者的生活质量，值得临床推广。
목적：관찰록과다태련용갑안접령치료합병골질소송적류풍습관절염환적료효。방법：72례합병골질소송적류풍습관절염환자수궤평분위대조조화치료조，대조조채용갑안접령；치료조채용록과다태주사액급갑안접령，비교량조효과。결과：치료조총유효솔、쌍완관절골밀도균현저고우대조조（P<0.05）；치료후량조환자ESR、RF、CRP수평균현저저우치료전（P<0.05），차치료조균저우대조조（P<0.05）；치료조병정복발솔현저저우대조조（P<0.05），량조치료기간균미견약물불량반응。결론：록과다태연합갑안접령치료합병골질소송증적류풍습관절염환자구유량호료효，능현저제고환자적생활질량，치득림상추엄。
Objective:To observe the efficacy of cervus and cucumis polypeptide and methotrexate treating rheumatoid arthritis combined with osteo-porosis. Methods:72 cases of patients with rheumatoid arthritis combined with osteoporosis were divided equally into control group and treatment group, control group used methotrexate, treatment group adopted cervus and cucumis polypeptide injection and methotrexate, effects between the two groups was compared. Results:The total effective rate and bone density of bilateral wrist of treatment group were both higher than those of con-trol group (P<0.05);after treatment ESR, RF and CRP of the two groups were all significantly lower than those before treatment (P<0.05), and treat-ment group was lower than control group (P<0.05);relapse rate of treatment group was significantly lower than that of control group (P<0.05), both without adverse drug reactions during the treatment. Conclusion:Cervus and cucumis polypeptide and methotrexate has good effect in rheumatoid ar-thritis combined with osteoporosis, which can significantly improve the life quality of patient's, being worthy of clinical application.