浙江预防医学
浙江預防醫學
절강예방의학
ZHEJIANG JOURNAL OF PREVENTIVE MEDICINE
2014年
11期
1081-1084
,共4页
刘灿磊%姚军%苏美芳%陈永弟%施海云%尹银香%尚建斌%陈丹
劉燦磊%姚軍%囌美芳%陳永弟%施海雲%尹銀香%尚建斌%陳丹
류찬뢰%요군%소미방%진영제%시해운%윤은향%상건빈%진단
乙肝疫苗%甲乙肝联合疫苗%加强免疫%免疫效果
乙肝疫苗%甲乙肝聯閤疫苗%加彊免疫%免疫效果
을간역묘%갑을간연합역묘%가강면역%면역효과
Booster immunization%Hepatitis Bvaccine%Hepatitis A and Bcombined vaccine%Immune effect
目的：评价儿童乙肝疫苗不同剂量加强免疫1剂后的免疫效果，为实施乙肝疫苗加强免疫提供依据。方法选择玉环县户籍5～11岁且1岁内完成乙肝疫苗基础免疫但未加强免疫的儿童，分别采用含5μg 甲乙肝联合疫苗547人和10μg 乙肝疫苗688人加强免疫1剂，在加强免疫前、后1个月分别检测乙型肝炎表面抗体（抗－HBs）浓度水平。结果加强免疫1个月后，使用含5μg 和10μg 两组儿童抗－HBs 阳性率分别为97.81％和96.08％，抗－HBs GMT 分别为1433.18和2111.43 mIU /mL。加强免疫前抗－HBs 阴性儿童抗－HBs阳转率分别为94.78％和93.62％；年龄越小，免疫阳转率越高（P ＜0.05）。加强免疫前后，两种不同剂量疫苗在抗－HBs 阳性率和抗－HBs GMT 的差异均有统计学意义（P ＜0.01）；抗－HBs GMT 差值均数10μg 乙肝疫苗高于含5μg 甲乙肝联合疫苗（P ＜0.05）。多因素分析提示，5岁以上儿童加强免疫，年龄越小其阳转率越高（OR ＝0.698，95％CI 为0.602～0.808）。结论5～11岁儿童加强乙肝免疫无论剂量大小均有较好的效果，年龄越小其免疫反应越好；10μg 乙肝疫苗加强后的抗－HBs GMT 高于含5μg 甲乙肝联合疫苗。
目的：評價兒童乙肝疫苗不同劑量加彊免疫1劑後的免疫效果，為實施乙肝疫苗加彊免疫提供依據。方法選擇玉環縣戶籍5～11歲且1歲內完成乙肝疫苗基礎免疫但未加彊免疫的兒童，分彆採用含5μg 甲乙肝聯閤疫苗547人和10μg 乙肝疫苗688人加彊免疫1劑，在加彊免疫前、後1箇月分彆檢測乙型肝炎錶麵抗體（抗－HBs）濃度水平。結果加彊免疫1箇月後，使用含5μg 和10μg 兩組兒童抗－HBs 暘性率分彆為97.81％和96.08％，抗－HBs GMT 分彆為1433.18和2111.43 mIU /mL。加彊免疫前抗－HBs 陰性兒童抗－HBs暘轉率分彆為94.78％和93.62％；年齡越小，免疫暘轉率越高（P ＜0.05）。加彊免疫前後，兩種不同劑量疫苗在抗－HBs 暘性率和抗－HBs GMT 的差異均有統計學意義（P ＜0.01）；抗－HBs GMT 差值均數10μg 乙肝疫苗高于含5μg 甲乙肝聯閤疫苗（P ＜0.05）。多因素分析提示，5歲以上兒童加彊免疫，年齡越小其暘轉率越高（OR ＝0.698，95％CI 為0.602～0.808）。結論5～11歲兒童加彊乙肝免疫無論劑量大小均有較好的效果，年齡越小其免疫反應越好；10μg 乙肝疫苗加彊後的抗－HBs GMT 高于含5μg 甲乙肝聯閤疫苗。
목적：평개인동을간역묘불동제량가강면역1제후적면역효과，위실시을간역묘가강면역제공의거。방법선택옥배현호적5～11세차1세내완성을간역묘기출면역단미가강면역적인동，분별채용함5μg 갑을간연합역묘547인화10μg 을간역묘688인가강면역1제，재가강면역전、후1개월분별검측을형간염표면항체（항－HBs）농도수평。결과가강면역1개월후，사용함5μg 화10μg 량조인동항－HBs 양성솔분별위97.81％화96.08％，항－HBs GMT 분별위1433.18화2111.43 mIU /mL。가강면역전항－HBs 음성인동항－HBs양전솔분별위94.78％화93.62％；년령월소，면역양전솔월고（P ＜0.05）。가강면역전후，량충불동제량역묘재항－HBs 양성솔화항－HBs GMT 적차이균유통계학의의（P ＜0.01）；항－HBs GMT 차치균수10μg 을간역묘고우함5μg 갑을간연합역묘（P ＜0.05）。다인소분석제시，5세이상인동가강면역，년령월소기양전솔월고（OR ＝0.698，95％CI 위0.602～0.808）。결론5～11세인동가강을간면역무론제량대소균유교호적효과，년령월소기면역반응월호；10μg 을간역묘가강후적항－HBs GMT 고우함5μg 갑을간연합역묘。
Objective To evaluate the effect on the booster immunization of different dosage of hepatitis B vaccine among children and to provide suggestions for booster immunization.Methods Children aged 5 -1 4 years old were randomly selected who had received the primary immunization of hepatitis B vaccine under 1 year old but had not received the booster immunization in Yuhuan county.A total of 547 children received 5 μg hepatitis A and B combined vaccine boost immunization and 688 children received 1 0 μg hepatitis B vaccine boost immunization in 2009.The anti -HBs levels before and after the boost immunization were detected.Results The anti -HBs positive rates of children received 5 μg and 1 0 μg vaccine boost immunization were 97.81 % and 96.08% respectively and the positive rates in the antibody negative children were 94.78% and 93.62% respectively.While the Geometric Mean Titer (GMT) of anti -HBs were 1 433.1 8 mIU /mL and 21 1 1 .43 mIU /mL respectively,which were both significantly higher than those before the boost immunization (P <0.001 ).The increase of GMT of children received 1 0 μg hepatitis B vaccine was significantly higher than that of children received 5 μg hepatitis A and B combined vaccine (P <0.05).Conclusion Both dosages of hepatitis B vaccine booster immunization are effective for children aged 5 -1 4 years old and 1 0 μg hepatitis B vaccine boost immunization has the better effect.
