CAJ | 학술논문

目的：探讨细菌溶解产物在预防慢性阻塞性肺疾病（COPD）急性发作中的成本-效益。方法使用成本-效益分析法，对象为接受细菌溶解产物治疗的COPD患者，成本为通过德尔菲法获得单次治疗COPD急性发作的医疗费用，效果指标为通过荟萃分析得到的随访期为12个月内患者COPD急性发作次数。使用单因素敏感性分析对参数变化对结果的影响进行识别。结果在对COPD的常规治疗中加入细菌溶解产物制剂能明显降低COPD患者12个月内的急性发作次数，降低患者的医疗负担，敏感性分析显示这一结果稳健。相比于单用常规治疗的患者，加用细菌溶解产物的患者平均少1.9次COPD急性发作，平均节省医疗费用14476元。结论对于COPD患者，在治疗中使用细菌溶解产物能减少急性发作次数，降低患者医疗费用。
목적：탐토세균용해산물재예방만성조새성폐질병（COPD）급성발작중적성본-효익。방법사용성본-효익분석법，대상위접수세균용해산물치료적COPD환자，성본위통과덕이비법획득단차치료COPD급성발작적의료비용，효과지표위통과회췌분석득도적수방기위12개월내환자COPD급성발작차수。사용단인소민감성분석대삼수변화대결과적영향진행식별。결과재대COPD적상규치료중가입세균용해산물제제능명현강저COPD환자12개월내적급성발작차수，강저환자적의료부담，민감성분석현시저일결과은건。상비우단용상규치료적환자，가용세균용해산물적환자평균소1.9차COPD급성발작，평균절성의료비용14476원。결론대우COPD환자，재치료중사용세균용해산물능감소급성발작차수，강저환자의료비용。
Objective The purpose of this study was to conduct a cost-benefit analysis of bacterial lysates from a payer perspective through the results from a Meta analysis and a Delphi panel survey in China.Methods A cost-benefit analysis was to project the 12-month health benefits and costs associated with immune stimulation treatments. Acute exacerbations were served as a measure of effectiveness. Treatment effectiveness data were derived from the meta-analysis. Costs were obtained from a Delphi panel survey of treating acute exacerbation for chronic obstructive pulmonary disease in China.Results The group receiving routine care only was dominated by the group with bacterial lysates plus routine care. Sensitivity analysis proved the robustness of the results. For a COPD patient, compared to the routine care as control group, the alternative treatment with bacterial lysates could reduce 1.9 exacerbations in 12 months. The projected 12-month cost savings of a patient receiving bacterial lysates plus routine care was CNY14 476.The cost of patients receiving bacterial lysates plus routine care was significantly lower than those receiving routine care only.Conclusion For patients with COPD, treatments with bacterial lysates can improve patient outcomes and reduce costs.