CAJ | 학술논문

小分子 RNA（microRNA）的发现是分子生物学史上的又一个里程碑。microRNA是一组单链非编码的RNA，由19～25个核苷酸（平均22个核苷酸）组成。研究证实microRNA在生理及病理状态下调节转录后的基因表达。其调节功能与细胞周期的调节，细胞增殖分化，炎症反应及凋亡相关。在许多病理状态下观察到 microRNA表达谱的改变，如糖尿病，类风湿性关节炎以及一些癌症。本综述对microRNA与妇科肿瘤的相关文献进行复习，总结microRNA在妇科肿瘤的发病机制中的可能作用，讨论microRNA作为妇科肿瘤早期诊断和治疗监控的肿瘤标记物的可能性，并对microRNAs在妇科肿瘤中作为治疗靶点和预后判断因素的可能性进行讨论。
소분자 RNA（microRNA）적발현시분자생물학사상적우일개리정비。microRNA시일조단련비편마적RNA，유19～25개핵감산（평균22개핵감산）조성。연구증실microRNA재생리급병리상태하조절전록후적기인표체。기조절공능여세포주기적조절，세포증식분화，염증반응급조망상관。재허다병리상태하관찰도 microRNA표체보적개변，여당뇨병，류풍습성관절염이급일사암증。본종술대microRNA여부과종류적상관문헌진행복습，총결microRNA재부과종류적발병궤제중적가능작용，토론microRNA작위부과종류조기진단화치료감공적종류표기물적가능성，병대microRNAs재부과종류중작위치료파점화예후판단인소적가능성진행토론。
The discovery of MicroRNA is another milestone in the history of molecular biology. MicroRNA is a group of single noncoding RNA that consists of 19-25 nucleotides (an average of 22 nucleotides). Study has verified that MicroRNA in physiological and pathological state regulates the transcription of gene expression. Its regulating function is related with regulation of cell cycle, cell proliferation differentiation, inflammation, and apoptosis. In many pathological conditions such as diabetes, rheumatoid arthritis and some cancers, MicroRNA expression changes. This abstract reviewed the pertinent literature of MicroRNA and gynecological tumor, summarized the possible role of MicroRNA in the pathogenesis of gynecological tumors, discussed the possibility of MicroRNA acting as tumor markers in early diagnosis and supervisory treatment and discussed the the possibility of MicroRNA acting as therapeutic targets and the prognostic factors in gynecological tumors .