CAJ | 학술논문

结直肠癌是最常见的消化道恶性肿瘤之一，其发病原因除了饮食、环境以及遗传因素外，越来越多的证据指向肠道菌群失调与结直肠癌发生发展有密切的关系。许多元基因组学的研究为揭示肠道微生物在结直肠癌发生发展中起到的作用提供了大量科学依据。在这篇综述中，我们会介绍结直肠癌患者肠道微生物多样性的研究进展，并总结结直肠癌发生发展相关的细菌及其研究现状。
결직장암시최상견적소화도악성종류지일，기발병원인제료음식、배경이급유전인소외，월래월다적증거지향장도균군실조여결직장암발생발전유밀절적관계。허다원기인조학적연구위게시장도미생물재결직장암발생발전중기도적작용제공료대량과학의거。재저편종술중，아문회개소결직장암환자장도미생물다양성적연구진전，병총결결직장암발생발전상관적세균급기연구현상。
Colorectal cancer (CRC) presents a considerable disease burden worldwide. Besides the diet, the environment, and the genetic factors, it is increasingly evident that dysbiosis of gut microbiota plays a role in the pathogenesis of in CRC. The increasing accessibility of microbial metagenomics is fueling a surge in our understanding of the role that microbes and the microbiota play in CRC. Some specific gut bacteria have been proposed to be associated with the pathogenesis of CRC. In this review, we discussed recent insights into contributions of the microbiota to CRC. We also highlighted newfindings on candidate CRC-potentiating species and current knowledge gaps.