中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
22期
3986-3989
,共4页
崔青%赵文杰%马华刚%王文双%孙理兰
崔青%趙文傑%馬華剛%王文雙%孫理蘭
최청%조문걸%마화강%왕문쌍%손리란
甲地孕酮%子宫内膜增生%血管生成素1%血管生成素2%受体,TIE-1
甲地孕酮%子宮內膜增生%血管生成素1%血管生成素2%受體,TIE-1
갑지잉동%자궁내막증생%혈관생성소1%혈관생성소2%수체,TIE-1
Megestrol%Endometrial hyperplasia%Angiopoietin-1%Angiopoietin-2%Receptor,TIE-1
目的：检测子宫内膜不典型增生患者应用甲地孕酮治疗前、治疗后 Ang-1、Ang-2及受体Tie-2的表达水平，探讨Angs/Tie-2信号途径在甲地孕酮治疗子宫内膜不典型增生中的作用。方法选取2011年1月至2013年8月，行病理组织活检确诊为子宫内膜不典型增生的患者26例作为试验组，同时间确诊为正常子宫内膜患者19例作为对照组，试验组常规应用甲地孕酮3个月， Western blot和RT-PCR检测对照组、试验组用药前、用药后Ang-1、Ang-2以及Tie-2的表达。结果26例试验组的患者中，14例显效，9例有效，总有效率88.46%。与对照组相比，Western blot与RT-PCR的结果均显示，子宫内膜不典型增生患者，Ang-1呈低表达，Ang-2、Tie-2呈高表达。应用甲地孕酮治疗后，Ang-1表达增高，而 Ang-2、Tie-2表达降低，差异有统计学意义（P＜0.05）。结论甲地孕酮是治疗子宫内膜不典型增生的有效药物，其治疗效果可能是通过Angs/Tie-2信号途径来实现的。
目的：檢測子宮內膜不典型增生患者應用甲地孕酮治療前、治療後 Ang-1、Ang-2及受體Tie-2的錶達水平，探討Angs/Tie-2信號途徑在甲地孕酮治療子宮內膜不典型增生中的作用。方法選取2011年1月至2013年8月，行病理組織活檢確診為子宮內膜不典型增生的患者26例作為試驗組，同時間確診為正常子宮內膜患者19例作為對照組，試驗組常規應用甲地孕酮3箇月， Western blot和RT-PCR檢測對照組、試驗組用藥前、用藥後Ang-1、Ang-2以及Tie-2的錶達。結果26例試驗組的患者中，14例顯效，9例有效，總有效率88.46%。與對照組相比，Western blot與RT-PCR的結果均顯示，子宮內膜不典型增生患者，Ang-1呈低錶達，Ang-2、Tie-2呈高錶達。應用甲地孕酮治療後，Ang-1錶達增高，而 Ang-2、Tie-2錶達降低，差異有統計學意義（P＜0.05）。結論甲地孕酮是治療子宮內膜不典型增生的有效藥物，其治療效果可能是通過Angs/Tie-2信號途徑來實現的。
목적：검측자궁내막불전형증생환자응용갑지잉동치료전、치료후 Ang-1、Ang-2급수체Tie-2적표체수평，탐토Angs/Tie-2신호도경재갑지잉동치료자궁내막불전형증생중적작용。방법선취2011년1월지2013년8월，행병리조직활검학진위자궁내막불전형증생적환자26례작위시험조，동시간학진위정상자궁내막환자19례작위대조조，시험조상규응용갑지잉동3개월， Western blot화RT-PCR검측대조조、시험조용약전、용약후Ang-1、Ang-2이급Tie-2적표체。결과26례시험조적환자중，14례현효，9례유효，총유효솔88.46%。여대조조상비，Western blot여RT-PCR적결과균현시，자궁내막불전형증생환자，Ang-1정저표체，Ang-2、Tie-2정고표체。응용갑지잉동치료후，Ang-1표체증고，이 Ang-2、Tie-2표체강저，차이유통계학의의（P＜0.05）。결론갑지잉동시치료자궁내막불전형증생적유효약물，기치료효과가능시통과Angs/Tie-2신호도경래실현적。
Objective To study the expression of angiopoietin(Ang)-1, Ang-2 and their receptor andothelium specific receptor tyrosine kinase (Tie)-2 in the treatment of megestrol acetate in endometrial atypical hyperplasia.Methods From January 2011 to August 2013, 26 cases of the endometrial atypical hyperplasia as experimental group and 19 cases of the normal endometrium as control group, were included in the study. All the experimental group’ patients were treated with megestrol acetate, the expression of Ang-1, Ang-2, Tie-2 were detected among the control group and the experimental group of pre-administration and post-administration.Results In the experimental group, 14 cases had marked effect, 9 were effective and total efficiency was 88.46%. Compared with the control group, Western blot and RT-PCR results were displayed that Ang-1 is low-expression while Ang-2 and Tie-2 has higher expression in patients with atypical endometrial hyperplasia. After application of megestrol acetate treatment, Ang-1 expression increased while Ang-2 and Tie-2 expression decreased significantly(P<0.05). Conclusion Megestrol acetate is an effective drug in curing atypical hyperplasia, and it may be achieved by Angs/Tie-2 signal pathway.
