中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
22期
3978-3981
,共4页
红斑狼疮,系统性%危险因素%类固醇糖尿病
紅斑狼瘡,繫統性%危險因素%類固醇糖尿病
홍반랑창,계통성%위험인소%류고순당뇨병
Lupus erythematosus,systemic%Risk factors%Steroid diabetes mellitus
目的:分析系统性红斑狼疮(SLE)并发类固醇糖尿病(SDM)患者的临床特点和危险因素。方法回顾性分析2006年2月至2013年6月在广州医科大学附属第二医院住院的14例并发SDM的SLE患者临床资料,并与性别、发病年龄相匹配的100例无合并SDM的SLE患者比较。结果14例SLE合并SDM患者中男1例,女13例,平均年龄(48.0±10.3)岁。4例SDM患者出现“三多一少”症状,4例空腹和餐后血糖均升高,10例餐后血糖升高。SDM患者使用口服降血糖药和(或)胰岛素治疗。单因素比较发现,SLE并发SDM组患者关节炎、肾脏病变、高血压、高胆固醇血症、高甘油三酯血症、高尿酸血症患者增多,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,高胆固醇血症是SLE患者并发SDM独立危险因素(OR 12.942,95% CI:2.994~41.316,P=0.000)。结论 SLE患者并发SDM患者关节炎、肾脏病变、高血压、高胆固醇血症、高甘油三酯血症、高尿酸血症者增多,高胆固醇血症是SLE患者并发SDM独立危险因素。
目的:分析繫統性紅斑狼瘡(SLE)併髮類固醇糖尿病(SDM)患者的臨床特點和危險因素。方法迴顧性分析2006年2月至2013年6月在廣州醫科大學附屬第二醫院住院的14例併髮SDM的SLE患者臨床資料,併與性彆、髮病年齡相匹配的100例無閤併SDM的SLE患者比較。結果14例SLE閤併SDM患者中男1例,女13例,平均年齡(48.0±10.3)歲。4例SDM患者齣現“三多一少”癥狀,4例空腹和餐後血糖均升高,10例餐後血糖升高。SDM患者使用口服降血糖藥和(或)胰島素治療。單因素比較髮現,SLE併髮SDM組患者關節炎、腎髒病變、高血壓、高膽固醇血癥、高甘油三酯血癥、高尿痠血癥患者增多,差異有統計學意義(P<0.05)。多因素Logistic迴歸分析顯示,高膽固醇血癥是SLE患者併髮SDM獨立危險因素(OR 12.942,95% CI:2.994~41.316,P=0.000)。結論 SLE患者併髮SDM患者關節炎、腎髒病變、高血壓、高膽固醇血癥、高甘油三酯血癥、高尿痠血癥者增多,高膽固醇血癥是SLE患者併髮SDM獨立危險因素。
목적:분석계통성홍반랑창(SLE)병발류고순당뇨병(SDM)환자적림상특점화위험인소。방법회고성분석2006년2월지2013년6월재엄주의과대학부속제이의원주원적14례병발SDM적SLE환자림상자료,병여성별、발병년령상필배적100례무합병SDM적SLE환자비교。결과14례SLE합병SDM환자중남1례,녀13례,평균년령(48.0±10.3)세。4례SDM환자출현“삼다일소”증상,4례공복화찬후혈당균승고,10례찬후혈당승고。SDM환자사용구복강혈당약화(혹)이도소치료。단인소비교발현,SLE병발SDM조환자관절염、신장병변、고혈압、고담고순혈증、고감유삼지혈증、고뇨산혈증환자증다,차이유통계학의의(P<0.05)。다인소Logistic회귀분석현시,고담고순혈증시SLE환자병발SDM독립위험인소(OR 12.942,95% CI:2.994~41.316,P=0.000)。결론 SLE환자병발SDM환자관절염、신장병변、고혈압、고담고순혈증、고감유삼지혈증、고뇨산혈증자증다,고담고순혈증시SLE환자병발SDM독립위험인소。
ObjectiveTo analyzeclinical characteristics and risk factors of steroid diabetes mellitus (SDM) in patients with systemic lupus erythematosus (SLE).MethodsFourteen medical records of SLE patients with SDM and 100 randomly-matched records of SLE patients without SDM were reviewed, the clinical data were compared between the two groups.Results Fourteen patients with SLE complicating with SDM included 1 man and 13 women, with the mean age of (48.0±10.3)years. Four patients of them had diuresis, polydipsia, polyphagia or maransis. Four patients with SDM had high fasting blood glucose and high postprandial blood glucose, and ten patients with SDM had high postprandial blood glucose. Hypoglycemic drugs and/or insulin were prescribed for patients with SDM. There was significant difference between SLE patients with SDM and SLE patients without SDM in arthritis, nephropathy, hypertension, hypercholesterolemia, hypertriglyceridemia, hyperuricemia (P<0.05). Hypercholesterolemia was an independent risk factor for SDM in SLE patients(OR 12.94, 95%CI 2.994-41.316,P=0.000). ConclusionsThere is an increased rate for SLE patients with SDM in arthritis, nephropathy, hypertension, hypercholesterolemia, hypertriglyceridemia and hyperuricemia. Hypercholesterolemia is an independent risk factor for SDM in SLE patients.