CAJ | 학술논문

目的：探讨冠心病患者血浆B型脑钠肽（BNP）水平与其冠状动脉病变程度的关系。方法136例行冠状动脉造影（CAG）检查者，CAG正常者30例作为对照组；冠心病患者106例，根据冠状动脉病变支数分1支、2支、3支病变组分别为38例、36例、32例；按冠状动脉病变类型分A型、B型、C型病变组分别为42例、36例、28例。分析BNP水平在冠状动脉病变不同支数组、不同类型冠状动脉病变组间的关系。结果随着冠状动脉病变支数的增加，BNP明显增高，三支病变组较单支、双支差异有统计学意义（P＜0.01）；随着冠状动脉病变类型严重程度的增加，BNP明显增高，BNP 在冠状动脉病变正常组、A 型、B 型、C 型病变组间两两比较差异均有统计学意义（P＜0.05），左心室舒张末期压力（LVEDP）在上述组间两两比较差异均有统计学意义（P＜0.01），直线相关回归分析表明BNP水平与Gensini积分存在明显正相关关系（r＝0.463，P＜0.01）。结论 BNP可反映冠状动脉粥样硬化病变的程度，其能较灵敏地反映左心室功能受损的血流动力学变化。
목적：탐토관심병환자혈장B형뇌납태（BNP）수평여기관상동맥병변정도적관계。방법136례행관상동맥조영（CAG）검사자，CAG정상자30례작위대조조；관심병환자106례，근거관상동맥병변지수분1지、2지、3지병변조분별위38례、36례、32례；안관상동맥병변류형분A형、B형、C형병변조분별위42례、36례、28례。분석BNP수평재관상동맥병변불동지수조、불동류형관상동맥병변조간적관계。결과수착관상동맥병변지수적증가，BNP명현증고，삼지병변조교단지、쌍지차이유통계학의의（P＜0.01）；수착관상동맥병변류형엄중정도적증가，BNP명현증고，BNP 재관상동맥병변정상조、A 형、B 형、C 형병변조간량량비교차이균유통계학의의（P＜0.05），좌심실서장말기압력（LVEDP）재상술조간량량비교차이균유통계학의의（P＜0.01），직선상관회귀분석표명BNP수평여Gensini적분존재명현정상관관계（r＝0.463，P＜0.01）。결론 BNP가반영관상동맥죽양경화병변적정도，기능교령민지반영좌심실공능수손적혈류동역학변화。
ObjectiveTo investigate the relationship between plasma level of brain natriuretic peptide(BNP) and the severity of coronary lesions in patients with coronary artery disease(CAD). Methods136 cases undergoing coronary angiography (CAG) and left ventricular pressure curves recording during CAG were enrolled. Among them there were 30 cases without CAD and 106 cases with CAD. The patients were further divided into 38 single-, 36 double-, 32 triple vessel disease groups and 42 A-, 36 B-, 28 C type of coronary lesions. Plasma BNP concentration was measured by radioimmunoassay. Left ventricular end-distolic pressure(LVEDP) were recorded by left ventricular pressure curves. Gensini score indicated the result of CAG. The relationship between BNP and the severity of coronary disease was analyzed.Results The levels of BNP, LVEDP and Gensini score were significantly different between 3 vessel group and 1, 2 vessel group, these parameters were also significantly different between A, B and C group.The BNP level were closely associated with Gensini score (r=0.463,P<0.01).Conclusion The plasma level of BNP can reflect the severity of coronary lesions to some extend, also was a sensitive biochemical marker for cardiac dysfunction.