CAJ | 학술논문

目的：探索不同程度首发抑郁障碍患者认知功能的特点。方法采用重复性成套神经心理状态测验（RBANS），对入选的297例首发抑郁障碍患者及242名正常人群进行测试。结果不同程度抑郁患者组在RBANS测试中总分明显低于正常组（F＝24.082，P＜0.001），轻度抑郁患者组测量总分低于中度抑郁患者组（P＜0.05）；不同程度抑郁患者组在即刻记忆、视觉广度、语言功能和延时记忆四个维度得分均低于正常组（P＜0.001）。RBANS各因子与HAMD各因子相关性分析发现焦虑/躯体化因子与即刻记忆、言语功能和延时记忆呈负相关（P＜0.05）；认识障碍因子与即刻记忆和言语功能呈负相关（P＜0.05）；日夜变化因子与即刻记忆呈负相关（P＜0.05）；阻滞因子与即刻记忆、言语功能、注意和延时记忆呈负相关（P＜0.05）；睡眠变化因子与即刻记忆、言语功能和延时记忆呈负相关（P＜0.05）；绝望感因子与言语功能呈负相关（P＜0.05）。结论不同程度首发抑郁障碍患者的认知功能存在不同程度的受损，认知功能各因子与抑郁症状各因子之间具有相关性。
목적：탐색불동정도수발억욱장애환자인지공능적특점。방법채용중복성성투신경심리상태측험（RBANS），대입선적297례수발억욱장애환자급242명정상인군진행측시。결과불동정도억욱환자조재RBANS측시중총분명현저우정상조（F＝24.082，P＜0.001），경도억욱환자조측량총분저우중도억욱환자조（P＜0.05）；불동정도억욱환자조재즉각기억、시각엄도、어언공능화연시기억사개유도득분균저우정상조（P＜0.001）。RBANS각인자여HAMD각인자상관성분석발현초필/구체화인자여즉각기억、언어공능화연시기억정부상관（P＜0.05）；인식장애인자여즉각기억화언어공능정부상관（P＜0.05）；일야변화인자여즉각기억정부상관（P＜0.05）；조체인자여즉각기억、언어공능、주의화연시기억정부상관（P＜0.05）；수면변화인자여즉각기억、언어공능화연시기억정부상관（P＜0.05）；절망감인자여언어공능정부상관（P＜0.05）。결론불동정도수발억욱장애환자적인지공능존재불동정도적수손，인지공능각인자여억욱증상각인자지간구유상관성。
ObjectiveTo explore the characteristics of cognitive function in different levels first-episode patients with major depression.Methods Using Repeatable Battery for the Assessment of Neuropsychological Status(RBANS) tested 297 patients and 242 normal people.ResultsThe RBANS total scores of first-episode depressive patients in different levels were significantly lower than control group (F=24.082,P<0.001). Compared to moderate depressive patients, the mild group had a lower RBANS scores(P<0.05). Compared to normal group, the scores in immediate memory, visual span, language function, and delayed memory were lower(P<0.001). Correlation test showed that, RBANS immediate memory, language function, and delayed memory had a negative correlation with anxiety/somatization factor(P<0.05). There was a negative correlation between cognitive impairment factors and RBANS immediate memory, language function(P<0.05). Day and night changing factor had negatively related with immediate memory(P<0.05). Retardation factor had negatively related with immediate memory, language features, attention and delayed memory(P<0.05). Sleep changing factor had negatively related with immediate memory, language function and delayed memory(P<0.05). Hopelessness factor had negatively related with language features(P<0.05). ConclusionDifferent levels of first-episode depressive patients have different damage in cognitive function. There is a correlation between depression factors and RMANS factors.