中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
22期
3962-3965
,共4页
李广连%国滨%李金芳%李铭%张振坤
李廣連%國濱%李金芳%李銘%張振坤
리엄련%국빈%리금방%리명%장진곤
胃肿瘤%放射疗法,适形%替吉奥%奥沙利铂
胃腫瘤%放射療法,適形%替吉奧%奧沙利鉑
위종류%방사요법,괄형%체길오%오사리박
Stomach neoplasms%Radiotherapy,conformal%TS-1%Oxaliplatin
目的：探讨进展期胃癌术后辅助化疗后序贯三维适形放疗后能否提高局部区域控制率，减少局部复发并延长生存期，并探讨进展期胃癌术后辅助化疗后序贯三维适形放疗的安全性及耐受性。方法选取我院60例进展期胃癌术后的患者，随机分为A、B两组，A组为对照组，其为单纯术后化疗患者，共30例，给予术后辅助化疗6个周期，化疗方案：奥沙利铂130 mg/m2 d1＋替吉奥60 mg bid d1～28。B组为观察组，其为上述方案6周期化疗后给予瘤床区三维适形放疗患者，共30例。观察胃肠反应、血常规、肿瘤指标、肿瘤影像评价结果。采用SPSS 18.0软件包进行统计处理。结果经过治疗后，观察组白细胞、血红蛋白减少、胃肠道反应的发生要比对照组明显，差异有统计学意义（P＜0.05），但其不良反应轻，以Ⅰ～Ⅱ级居多，Ⅲ～Ⅳ级发生率极低；观察组和对照组1年内影像学评价复发转移分别为23.3%和40.0%，且差异有统计学意义（P＜0.05）；两组血清肿瘤标记物持续异常水平无统计学差异。结论进展期胃癌术后辅助性化疗后序贯三维适形放疗能够提高患者近期局部区域控制率，减少局部复发，疗效满意，但毒副作用明显，安全性及耐受性有待进一步探讨。
目的：探討進展期胃癌術後輔助化療後序貫三維適形放療後能否提高跼部區域控製率，減少跼部複髮併延長生存期，併探討進展期胃癌術後輔助化療後序貫三維適形放療的安全性及耐受性。方法選取我院60例進展期胃癌術後的患者，隨機分為A、B兩組，A組為對照組，其為單純術後化療患者，共30例，給予術後輔助化療6箇週期，化療方案：奧沙利鉑130 mg/m2 d1＋替吉奧60 mg bid d1～28。B組為觀察組，其為上述方案6週期化療後給予瘤床區三維適形放療患者，共30例。觀察胃腸反應、血常規、腫瘤指標、腫瘤影像評價結果。採用SPSS 18.0軟件包進行統計處理。結果經過治療後，觀察組白細胞、血紅蛋白減少、胃腸道反應的髮生要比對照組明顯，差異有統計學意義（P＜0.05），但其不良反應輕，以Ⅰ～Ⅱ級居多，Ⅲ～Ⅳ級髮生率極低；觀察組和對照組1年內影像學評價複髮轉移分彆為23.3%和40.0%，且差異有統計學意義（P＜0.05）；兩組血清腫瘤標記物持續異常水平無統計學差異。結論進展期胃癌術後輔助性化療後序貫三維適形放療能夠提高患者近期跼部區域控製率，減少跼部複髮，療效滿意，但毒副作用明顯，安全性及耐受性有待進一步探討。
목적：탐토진전기위암술후보조화료후서관삼유괄형방료후능부제고국부구역공제솔，감소국부복발병연장생존기，병탐토진전기위암술후보조화료후서관삼유괄형방료적안전성급내수성。방법선취아원60례진전기위암술후적환자，수궤분위A、B량조，A조위대조조，기위단순술후화료환자，공30례，급여술후보조화료6개주기，화료방안：오사리박130 mg/m2 d1＋체길오60 mg bid d1～28。B조위관찰조，기위상술방안6주기화료후급여류상구삼유괄형방료환자，공30례。관찰위장반응、혈상규、종류지표、종류영상평개결과。채용SPSS 18.0연건포진행통계처리。결과경과치료후，관찰조백세포、혈홍단백감소、위장도반응적발생요비대조조명현，차이유통계학의의（P＜0.05），단기불량반응경，이Ⅰ～Ⅱ급거다，Ⅲ～Ⅳ급발생솔겁저；관찰조화대조조1년내영상학평개복발전이분별위23.3%화40.0%，차차이유통계학의의（P＜0.05）；량조혈청종류표기물지속이상수평무통계학차이。결론진전기위암술후보조성화료후서관삼유괄형방료능구제고환자근기국부구역공제솔，감소국부복발，료효만의，단독부작용명현，안전성급내수성유대진일보탐토。
ObjectiveTo study the curative effect of sequential three-dimensional conformal radiotherapy after postoperative chemotherapy of S-1 combined oxaliplatin for advanced gastric cancer, whether it can improve the local control rates, reduce local recurrence and prolong survival period, and to explore the safety and tolerability.Methods60 patients with advanced gastric cancer after operation were collected, and randomly divided into A, B groups, group A was as the control group with pure postoperative chemotherapy, a total of 30 cases, was given postoperative adjuvant chemotherapy for 6 cycles, chemotherapy regimens: oxaliplatin 130 mg/m2 d1+TS-1 60 mg bid d1-28. Group B was as the observation group, given three-dimensional conformal radiotherapy after 6 cycles of chemotherapy, a total of 30 cases. Observed the gastrointestinal reaction, routine blood, tumor marker, tumor imaging evaluation results. SPSS 18.0 software was used for statistical analysis.Results After treatment, the decrease of white blood cells and hemoglobin, gastrointestinal reaction in observation group were obvious than the control group, the difference was statistically significant (P<0.05), but the adverse reaction was light,Ⅰ-Ⅱ degreewas in the majority,Ⅲ-Ⅳ was extremely low; recurrence and metastasis rates with imaging evaluation in 1 year of observation group and the control group were 23.3% and 40%, and the difference was statistically significant (P<0.05); serum tumor markers of two groups continued to abnormal levels had no significant difference.Conclusion Sequential three-dimensional conformal radiotherapy after postoperative chemotherapy of S-1 combined oxaliplatin for advanced gastric cancer can improve the recent local control rates, reduce local recurrence, curative effect is satisfied, but had obvious side effects, safety and tolerability remains to be further discussed.
