CAJ | 학술논문

目的：比较氟比洛芬酯与帕瑞昔布钠在腰椎后路内固定术后手术区域镇痛治疗中的疗效及安全性。方法：接受单节段腰椎后路内固定手术治疗的90例患者随机分为3组，每组30例，A组为术后氟比洛芬酯100 mg镇痛，B组为术后帕瑞昔布钠40 mg镇痛，C组为术后生理盐水对照组。记录术后2、6、12、24、48、72 h的疼痛VAS评分、术后追加盐酸曲马多用量和发生不良反应的例数，并进行统计学分析。结果：A、B组术后各时间点镇痛效果显著优于C组（P＜0．05）；C组术后追加阿片类镇痛药物用量显著多于A、B组（P＜0．05）；术后2 h，A组VAS评分显著低于B组；术后6、12、24 h，A组与B组VAS评分比较差异无统计学意义（P＞0．05），术后48、72 h A组VAS评分显著高于B组（P＜0．05）。C组不良反应例数显著少于A、B组（P＞0．05）， A、B组发生不良反应例数比较差异无统计学意义（P＞0．05）。结论：氟比洛芬酯与帕瑞昔布钠均能减轻术后疼痛且不良反应发生率低，以氟比洛芬酯起效更快，而帕瑞昔布钠长期镇痛效果更优。
목적：비교불비락분지여파서석포납재요추후로내고정술후수술구역진통치료중적료효급안전성。방법：접수단절단요추후로내고정수술치료적90례환자수궤분위3조，매조30례，A조위술후불비락분지100 mg진통，B조위술후파서석포납40 mg진통，C조위술후생리염수대조조。기록술후2、6、12、24、48、72 h적동통VAS평분、술후추가염산곡마다용량화발생불량반응적례수，병진행통계학분석。결과：A、B조술후각시간점진통효과현저우우C조（P＜0．05）；C조술후추가아편류진통약물용량현저다우A、B조（P＜0．05）；술후2 h，A조VAS평분현저저우B조；술후6、12、24 h，A조여B조VAS평분비교차이무통계학의의（P＞0．05），술후48、72 h A조VAS평분현저고우B조（P＜0．05）。C조불량반응례수현저소우A、B조（P＞0．05）， A、B조발생불량반응례수비교차이무통계학의의（P＞0．05）。결론：불비락분지여파서석포납균능감경술후동통차불량반응발생솔저，이불비락분지기효경쾌，이파서석포납장기진통효과경우。
Objective To compare the analgesia effect and the safety of Flurbiprofen Axetil (FA) and Parecoxib Sodium (PS) after posterior lumbar fusion surgery. Methods 90 patients undergoing internal fixation of lumbar spine randomly assigned to 3 groups:those in Group A(n = 30) received 100 mg of FA; those in Group B (n=30) received 40 mg of PS and those in Group C received saline.The VAS scores of 2, 6, 12, 24, 48, 72 h after operation and the dose of tramadol hydrochloride (TH) used and the side effect was recorded respectively. Results Group A and B had significantly better analgesic effect than Group C(P<0.05). Group A and B had lower average dose of TH than Group C (P<0.05). The VAS scores in Group A was lower than that in Group B in 2 h after the surgery. The VAS scores after the surgery showed no significant difference between Group A and B in 6 , 12, 24 h after the surgery. The VAS scores in Group A was higer than that in Group B in 48,72 h after the surgery. Conclusion Both PS and FA can alleviate postoperative pain and have fewer adverse reactions.