检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
22期
3089-3091
,共3页
miR-27a%基因多态性%乳腺癌%M eta分析
miR-27a%基因多態性%乳腺癌%M eta分析
miR-27a%기인다태성%유선암%M eta분석
miR-27a%polymorphism%breast cancer%Meta-analysis
目的：系统评价不同人群中微小RNAmiR‐27ars895819多态性与乳腺癌易感性的关系。方法计算机检索PubMed、EMBASE、CochraneLibrary、中国生物医学文献数据库（CBM）、中文科技期刊全文数据库（VIP）、中国期刊全文数据库（CNKI）及万方数据库，收集国内外发表的关于miR‐27a基因多态性与乳腺癌易感性的病例对照研究。检索时间均从建库至2014年6月，按纳入和排除标准筛选文献并评价纳入研究质量后，应用RevMan5．2软件进行Meta分析。结果该研究共纳入5篇文献，其中2篇在欧洲人群中进行研究，3篇在亚洲人群中进行研究。Meta分析结果显示：在总体人群与亚洲人群中miR‐27ars895819多态性与乳腺癌易感性无关，而在欧洲人群中有3个模型分析表明miR‐27ars895819多态性与乳腺癌易感性有关，分别为等位基因模型Gvs．A（OR＝0．89，95CI％：0．82～0．97，P＝0．008）；共显性模型AGvs．AA（OR＝0．83，95％CI：0．74～0．94，P＝0．002）；显性模型GG＋AGvs．AA（OR＝0．83，95％CI：0．75～0．91，P＝0．002）。结论在总体人群及亚洲人群中miR‐27rs895819多态性与乳腺癌易感性无关。然而在欧洲人群中miR‐27rs895819多态性与乳腺癌易感性有关。
目的：繫統評價不同人群中微小RNAmiR‐27ars895819多態性與乳腺癌易感性的關繫。方法計算機檢索PubMed、EMBASE、CochraneLibrary、中國生物醫學文獻數據庫（CBM）、中文科技期刊全文數據庫（VIP）、中國期刊全文數據庫（CNKI）及萬方數據庫，收集國內外髮錶的關于miR‐27a基因多態性與乳腺癌易感性的病例對照研究。檢索時間均從建庫至2014年6月，按納入和排除標準篩選文獻併評價納入研究質量後，應用RevMan5．2軟件進行Meta分析。結果該研究共納入5篇文獻，其中2篇在歐洲人群中進行研究，3篇在亞洲人群中進行研究。Meta分析結果顯示：在總體人群與亞洲人群中miR‐27ars895819多態性與乳腺癌易感性無關，而在歐洲人群中有3箇模型分析錶明miR‐27ars895819多態性與乳腺癌易感性有關，分彆為等位基因模型Gvs．A（OR＝0．89，95CI％：0．82～0．97，P＝0．008）；共顯性模型AGvs．AA（OR＝0．83，95％CI：0．74～0．94，P＝0．002）；顯性模型GG＋AGvs．AA（OR＝0．83，95％CI：0．75～0．91，P＝0．002）。結論在總體人群及亞洲人群中miR‐27rs895819多態性與乳腺癌易感性無關。然而在歐洲人群中miR‐27rs895819多態性與乳腺癌易感性有關。
목적：계통평개불동인군중미소RNAmiR‐27ars895819다태성여유선암역감성적관계。방법계산궤검색PubMed、EMBASE、CochraneLibrary、중국생물의학문헌수거고（CBM）、중문과기기간전문수거고（VIP）、중국기간전문수거고（CNKI）급만방수거고，수집국내외발표적관우miR‐27a기인다태성여유선암역감성적병례대조연구。검색시간균종건고지2014년6월，안납입화배제표준사선문헌병평개납입연구질량후，응용RevMan5．2연건진행Meta분석。결과해연구공납입5편문헌，기중2편재구주인군중진행연구，3편재아주인군중진행연구。Meta분석결과현시：재총체인군여아주인군중miR‐27ars895819다태성여유선암역감성무관，이재구주인군중유3개모형분석표명miR‐27ars895819다태성여유선암역감성유관，분별위등위기인모형Gvs．A（OR＝0．89，95CI％：0．82～0．97，P＝0．008）；공현성모형AGvs．AA（OR＝0．83，95％CI：0．74～0．94，P＝0．002）；현성모형GG＋AGvs．AA（OR＝0．83，95％CI：0．75～0．91，P＝0．002）。결론재총체인군급아주인군중miR‐27rs895819다태성여유선암역감성무관。연이재구주인군중miR‐27rs895819다태성여유선암역감성유관。
Objective To systematically evaluate the association between rs895819 polymorphism of microR‐NA miR‐27a and the susceptibility of breast cancer .Methods A computer‐based retrieval of PubMed ,EMBASE ,Co‐chrane Library ,CBM ,VIP ,CNKI and Wanfang Database from their establishment to June 2014 was performed for collecting the case‐control studies investigating the miR‐27a polymorphisms and the susceptibility of breast cancer published at home and abroad .The literature was screened according to the inclusion and exclusion criteria and the quality of studies was evaluated .Then the data were performed the Meta‐analysis by using RevMan 5 .2 software .Re‐sults 5 articles were included ,in which 2 articles were the study on European populations and 3 articles were the study on Asian populations .The Meta analysis showed that the miR27a rs895819 polymorphism had no relation with the breast cancer susceptibility in the total populations and Asian populations ,but the 3‐model analysis in the Europe‐an populations indicated that the miR27a rs895819 polymorphism was related with the breast cancer susceptibility , which were allele model G vs .A(OR=0 .89 ,95CI% :0 .82 -0 .97 ,P=0 .008) ,codominant model AG vs .AA(OR=0 .83 ,95% CI:0 .74-0 .94 ,P=0 .002)and dominant model GG+ AG vs .AA (OR=0 .83 ,95% CI:0 .75 -0 .91 ,P=0 .002)respectively .Conclusion The existing evidences reveal that the rs895819 polymorphism of the miR‐27a is not found to be associated with the susceptibility of breast cancer in total populations and Asian populations .However the rs895819 polymorphism of miR‐27a is associated with the susceptibility of breast cancer in European populations .
