中外医学研究
中外醫學研究
중외의학연구
CHINESE AND FOREIGN MEDICAL RESEARCH
2014年
32期
9-11
,共3页
急性重症胰腺炎%血清胆碱酯酶%预后
急性重癥胰腺炎%血清膽堿酯酶%預後
급성중증이선염%혈청담감지매%예후
Severe acute pancreatitis%Serum cholinesterase%Prognosis
目的：观察并探讨急性重症胰腺炎患者血清胆碱酯酶水平与预后的关系，为临床诊断病情和评估预后提供依据。方法：选取2011年1月-2014年1月在笔者所在医院接受急性重症胰腺炎治疗的50例患者作为研究组，同时选取50例健康志愿者作为对照组。研究组入院后抢救同时使用自动化分析仪器检测患者血清胆碱酯酶水平，对照组同样需要检测血清胆碱酯酶水平。统计信息并分析血清胆碱酯酶水平与患者APACHE-Ⅱ评分的关系，从而比较胆碱酯酶水平与预后的关系。结果：研究组血清胆碱酯酶在三个时间点的浓度水平均明显低于对照组，其中死亡组的血清胆碱酯酶水平明显低于存活组，存活组血清胆碱酯酶水平明显低于对照组，差异均有统计学意义(P<0.05)。患者血清胆碱酯酶水平与APACHE-Ⅱ评分呈反比，血清胆碱酯酶水平预测的准确性和阳性预测率均高于APACHE-Ⅱ评分，组间差异均有统计学意义(P<0.05)。结论：急性重症胰腺炎患者血清胆碱酯酶水平与其预后有着密切关联，具有较高的准确性和阳性预测率，可以作为临床上估计急性重症胰腺炎的病情、判断预后的有效指标，值得在临床上推广和使用。
目的：觀察併探討急性重癥胰腺炎患者血清膽堿酯酶水平與預後的關繫，為臨床診斷病情和評估預後提供依據。方法：選取2011年1月-2014年1月在筆者所在醫院接受急性重癥胰腺炎治療的50例患者作為研究組，同時選取50例健康誌願者作為對照組。研究組入院後搶救同時使用自動化分析儀器檢測患者血清膽堿酯酶水平，對照組同樣需要檢測血清膽堿酯酶水平。統計信息併分析血清膽堿酯酶水平與患者APACHE-Ⅱ評分的關繫，從而比較膽堿酯酶水平與預後的關繫。結果：研究組血清膽堿酯酶在三箇時間點的濃度水平均明顯低于對照組，其中死亡組的血清膽堿酯酶水平明顯低于存活組，存活組血清膽堿酯酶水平明顯低于對照組，差異均有統計學意義(P<0.05)。患者血清膽堿酯酶水平與APACHE-Ⅱ評分呈反比，血清膽堿酯酶水平預測的準確性和暘性預測率均高于APACHE-Ⅱ評分，組間差異均有統計學意義(P<0.05)。結論：急性重癥胰腺炎患者血清膽堿酯酶水平與其預後有著密切關聯，具有較高的準確性和暘性預測率，可以作為臨床上估計急性重癥胰腺炎的病情、判斷預後的有效指標，值得在臨床上推廣和使用。
목적：관찰병탐토급성중증이선염환자혈청담감지매수평여예후적관계，위림상진단병정화평고예후제공의거。방법：선취2011년1월-2014년1월재필자소재의원접수급성중증이선염치료적50례환자작위연구조，동시선취50례건강지원자작위대조조。연구조입원후창구동시사용자동화분석의기검측환자혈청담감지매수평，대조조동양수요검측혈청담감지매수평。통계신식병분석혈청담감지매수평여환자APACHE-Ⅱ평분적관계，종이비교담감지매수평여예후적관계。결과：연구조혈청담감지매재삼개시간점적농도수평균명현저우대조조，기중사망조적혈청담감지매수평명현저우존활조，존활조혈청담감지매수평명현저우대조조，차이균유통계학의의(P<0.05)。환자혈청담감지매수평여APACHE-Ⅱ평분정반비，혈청담감지매수평예측적준학성화양성예측솔균고우APACHE-Ⅱ평분，조간차이균유통계학의의(P<0.05)。결론：급성중증이선염환자혈청담감지매수평여기예후유착밀절관련，구유교고적준학성화양성예측솔，가이작위림상상고계급성중증이선염적병정、판단예후적유효지표，치득재림상상추엄화사용。
Objective:To observe and investigate the relation between serum cholinesterase level of patients with severe acute pancreatitis(SAP) and its prognosis,so as to provide basis for the clinical diagnosis and prognosis evaluation.Method:50 SAP patients treated in our hospital from January 2011 to January 2014 were selected as the research group,and selected another 50 healthy volunteers as the control group.The research group admitted to hospital after the rescue while using automated analytical instrument to detect serum cholinesterase levels,the control group also needed to detect serum cholinesterase levels.The information was counted and the relationship between serum cholinesterase levels and patients with APACHE-Ⅱscore was analyzed,which compared the relationship between cholinesterase levels and prognosis.Result:The serum cholinesterase level of research group at three time point were significantly lower than the control group,and the level of dead group were significantly lower than survival group,level of survival group were lower than the control group,the differences were statistically significant(P<0.05).The accuracy and positive predictive values of serum cholinesterase level were significantly higher than APACHE-Ⅱscore, the differences were statistically significant between groups(P<0.05).Conclusion:There is a close relation between SAP and serum cholinesterase,with higher accuracy and positive predictive values,it can be used as the effective indicators for judgement and prognosis of SAP and widely promoted in clinic.
