中国神经免疫学和神经病学杂志
中國神經免疫學和神經病學雜誌
중국신경면역학화신경병학잡지
CHINESE JOURNAL OF NEUROIMMUNOLOGY AND
2014年
6期
390-393
,共4页
蒋东晓%连艳芬%李振光%李海峰
蔣東曉%連豔芬%李振光%李海峰
장동효%련염분%리진광%리해봉
多发性硬化%溶血磷脂酸%酸性磷脂%超敏C反应蛋白
多髮性硬化%溶血燐脂痠%痠性燐脂%超敏C反應蛋白
다발성경화%용혈린지산%산성린지%초민C반응단백
multiple sclerosis%lysophosphatidic acid%acidic phospholipids%hypersensitive C-reactive pro-tein
目的：观察多发性硬化（MS）患者血浆中溶血磷脂酸（LPA）和酸性磷脂（AP）以及血清超敏C反应蛋白（Hs‐CRP）水平的变化，探讨这些炎性标志物与MS疾病活动程度的关系。方法选取14例急性期MS患者、15例缓解期MS患者及30名健康体检者，测定其血LPA、AP和 Hs‐CRP的水平变化。结果（1）急性期MS组治疗前血浆 LPA、AP和血清 Hs‐CRP水平均显著高于缓解期 MS组（P＜0.01）和健康对照组（P＜0.01）。（2）急性期MS组经治疗28 d后血浆LPA、AP和血清Hs‐CRP水平显著低于治疗前（P＜0.01）。（3）急性期MS组治疗前血浆LPA与AP水平存在相关性（r＝0.807，P＜0.01），急性期MS组治疗前血浆LPA和AP与血清Hs‐CRP水平存在相关性（r＝0.574，P＜0.05；r＝0.776，P＜0.01）。结论血浆LPA、AP和血清 Hs‐CRP水平可能作为MS患者疾病活动性的炎性标志物。
目的：觀察多髮性硬化（MS）患者血漿中溶血燐脂痠（LPA）和痠性燐脂（AP）以及血清超敏C反應蛋白（Hs‐CRP）水平的變化，探討這些炎性標誌物與MS疾病活動程度的關繫。方法選取14例急性期MS患者、15例緩解期MS患者及30名健康體檢者，測定其血LPA、AP和 Hs‐CRP的水平變化。結果（1）急性期MS組治療前血漿 LPA、AP和血清 Hs‐CRP水平均顯著高于緩解期 MS組（P＜0.01）和健康對照組（P＜0.01）。（2）急性期MS組經治療28 d後血漿LPA、AP和血清Hs‐CRP水平顯著低于治療前（P＜0.01）。（3）急性期MS組治療前血漿LPA與AP水平存在相關性（r＝0.807，P＜0.01），急性期MS組治療前血漿LPA和AP與血清Hs‐CRP水平存在相關性（r＝0.574，P＜0.05；r＝0.776，P＜0.01）。結論血漿LPA、AP和血清 Hs‐CRP水平可能作為MS患者疾病活動性的炎性標誌物。
목적：관찰다발성경화（MS）환자혈장중용혈린지산（LPA）화산성린지（AP）이급혈청초민C반응단백（Hs‐CRP）수평적변화，탐토저사염성표지물여MS질병활동정도적관계。방법선취14례급성기MS환자、15례완해기MS환자급30명건강체검자，측정기혈LPA、AP화 Hs‐CRP적수평변화。결과（1）급성기MS조치료전혈장 LPA、AP화혈청 Hs‐CRP수평균현저고우완해기 MS조（P＜0.01）화건강대조조（P＜0.01）。（2）급성기MS조경치료28 d후혈장LPA、AP화혈청Hs‐CRP수평현저저우치료전（P＜0.01）。（3）급성기MS조치료전혈장LPA여AP수평존재상관성（r＝0.807，P＜0.01），급성기MS조치료전혈장LPA화AP여혈청Hs‐CRP수평존재상관성（r＝0.574，P＜0.05；r＝0.776，P＜0.01）。결론혈장LPA、AP화혈청 Hs‐CRP수평가능작위MS환자질병활동성적염성표지물。
Objective To explore the levels of plasma lysophosphatidic acid (LPA) ,acidic phospholipid (AP) and serum hypersensitive C‐reactive protein (Hs‐CRP) in patients with multiple sclerosis (MS) ,and to explore the relationship between the levels of these inflammatory biomarkers and disease activity .Methods Blood samples were collected from 14 MS patients in acute phase ,15 MS patients in remitting period and 30 healthy volunteers .Changes of blood LPA ,AP and Hs‐CRP levels were measured .Results Levels of plasma LPA ,AP and serum Hs‐CRP before treatment in the acute phase group were significantly higher than those in the remitting group (P<0.01 respectively) and healthy control group (P<0.01 respectively) .Levels of plasma LPA ,AP and serum Hs‐CRP after treatment were significantly lower than those before treatment in the acute phase group (P<0.01 respectively) .Plasma levels of LPA before treatment were correlated with AP level in the acute phase group (r=0.807 , P<0.01) ,levels of plasma LPA and AP before treatment were correlated with serum Hs‐CRP level in the acute phase group (r=0.574 , P<0.05 ;r=0.776 , P<0.01) .Conclusions Levels of plasma LPA and AP and level of serum Hs‐CRP may be used as inflammatory biomarkers for disease activity in M S patients .
