CAJ | 학술논문

肺间质纤维化是各种不同病因肺间质疾病的共同结局,是呼吸衰竭的重要病因,其发病机制至今仍不明了.microRNA(miRNA)自发现以来即成为生命科学研究的重要热点,已发现miRNA的异常表达与多种人类疾病紧密相关.近年来的研究发现miRNA在肺间质纤维化的发病机制中起着重要作用,预示miRNA有望成为肺间质纤维化治疗的新靶点.
폐간질섬유화시각충불동병인폐간질질병적공동결국,시호흡쇠갈적중요병인,기발병궤제지금잉불명료.microRNA(miRNA)자발현이래즉성위생명과학연구적중요열점,이발현miRNA적이상표체여다충인류질병긴밀상관.근년래적연구발현miRNA재폐간질섬유화적발병궤제중기착중요작용,예시miRNA유망성위폐간질섬유화치료적신파점.
Pulmonary fibrosis is the common end-result of a variety of interstitial lung diseases with different etiological factors and is the important risk factor of respiratory failure.The pathogenesis of the disease is still unknown.MicroRNA (miRNA) has been the important hotspot of life science research since it is discovered.It has been confirmed that the abnormal expression of miRNA is invovled in the development of a series of human diseases.Recent studies have confirmed that miRNA plays an important role in the pathogenesis of pulmonary fibrosis,which indicates that miRNA may be evaluated as a novel target for treatment of the disease.