CAJ | 학술논문

目的：研究针刺对慢性应激抑郁型大鼠的治疗机制。方法：取SD雄性大鼠随机分为3组，空白组、模型组及针刺治疗组，其中模型组给予慢性刺激、孤养、造模；针刺治疗组造模同时电针治疗。21 d后观察各组海马组织的ERK1蛋白相对含量、肾上腺质量。结果：与空白组比较，模型组、治疗组肾上腺体积均增大，体重增加，存在统计学差异（ P<0.05），而模型组ERK1的蛋白含量显著减少（ P<0.05），针刺组与空白组无统计学差异（ P>0.05）；与模型组比较，针刺组肾上腺质量与其存在统计学差异（ P<0.05），针刺组ERK1蛋白相对含量较之有所升高（ P<0.05）。结论：针刺治疗抑郁症能有效改善肾上腺体积增大，并能活跃ERK通路。
목적：연구침자대만성응격억욱형대서적치료궤제。방법：취SD웅성대서수궤분위3조，공백조、모형조급침자치료조，기중모형조급여만성자격、고양、조모；침자치료조조모동시전침치료。21 d후관찰각조해마조직적ERK1단백상대함량、신상선질량。결과：여공백조비교，모형조、치료조신상선체적균증대，체중증가，존재통계학차이（ P<0.05），이모형조ERK1적단백함량현저감소（ P<0.05），침자조여공백조무통계학차이（ P>0.05）；여모형조비교，침자조신상선질량여기존재통계학차이（ P<0.05），침자조ERK1단백상대함량교지유소승고（ P<0.05）。결론：침자치료억욱증능유효개선신상선체적증대，병능활약ERK통로。
Objective:To investigate the mechanism of acupuncture for treatment of rats with chronic stress-induced depression. Methods:SD male rats were randomly divided into three groups,including the control group,model group and acupuncture treatment group. The model group underwent chronic irritation,neonatal isolation and modeling;while the treatment group underwent modeling and synchronous electro-acupuncture treatment. 21 days later,the relative level of ERK1 and adrenal mass in the hippocampus were observed in each group. Results:Compared with the blank group, the adrenal gland volume was increased in the model group and treatment group,as well as the body weight,with signifi-cant differences(P<0. 05);the protein level of ERK1 was significantly reduced in the model group(P<0. 05),while it was not different from the acupuncture group(P>0. 05). Compared with the model group,the adrenal mass in the acupuncture group was statistically different( P<0 . 05 ),and the relative protein level of ERK1 in the acupuncture group was increased( P<0 . 05 ). Conclusion:Acupuncture for treatment of depression can effectively be improved in the adrenal gland volume,and actively increase the ERK pathway.