CAJ | 학술논문

流感病毒融合肽在流感病毒感染宿主细胞的过程中扮演关键角色，解析其三维结构是了解病毒融合机制的关键。融合肽结构的研究历经十几年，期间提出了多种融合模型和假说，至今仍然是科学家们感兴趣的热点问题。核磁共振方法是研究融合肽结构的主要手段之一，该文综述了该领域近几年的重要进展，以期对流感病毒融合肽的融合机制有更深入的认识。
류감병독융합태재류감병독감염숙주세포적과정중분연관건각색，해석기삼유결구시료해병독융합궤제적관건。융합태결구적연구력경십궤년，기간제출료다충융합모형화가설，지금잉연시과학가문감흥취적열점문제。핵자공진방법시연구융합태결구적주요수단지일，해문종술료해영역근궤년적중요진전，이기대류감병독융합태적융합궤제유경심입적인식。
The influenza fusion peptide plays a pivotal role in the fusion process of the viral membrane with the host-cell endosomal membrane. Recent success of solving the structure of influenza hemagglutinin fusion peptide has led to a new understanding of the fusion mechanism. Although a few hypotheses have been proposed, it is still of great interest to investigate the structure-function relationship of the fusion peptide. In this paper, the progresses in the field for the last decade is reviewed.