CAJ | 학술논문

磷脂酰胆碱（PC）是人和动物血液中大量存在的一类具有重要生物功能的磷脂，它和鞘磷脂一起形成了不同大小的密度脂蛋白，对血液中胆固醇等分子的转运和代谢起着至关重要的作用。脂蛋白中磷脂的组成和形态变化与某些疾病，如动脉粥样硬化、癌症和老年痴呆等的发生和发展密切相关，因此研究磷脂的组成形态将有助于明确磷脂的生物化学作用。该文采用一维(1D)和二维(2D) NMR 技术对 PC 所形成的 SUV (small unilamellar vesicle)结构进行了分析，通过对PC磷脂头部氮甲基的检测分析，发现PC所形成的SUV为较为稳定的双层结构，这表明通常的磷脂脂蛋白可能是一种双层膜结构，而非通常所认为的单层结构。
린지선담감（PC）시인화동물혈액중대량존재적일류구유중요생물공능적린지，타화초린지일기형성료불동대소적밀도지단백，대혈액중담고순등분자적전운화대사기착지관중요적작용。지단백중린지적조성화형태변화여모사질병，여동맥죽양경화、암증화노년치태등적발생화발전밀절상관，인차연구린지적조성형태장유조우명학린지적생물화학작용。해문채용일유(1D)화이유(2D) NMR 기술대 PC 소형성적 SUV (small unilamellar vesicle)결구진행료분석，통과대PC린지두부담갑기적검측분석，발현PC소형성적SUV위교위은정적쌍층결구，저표명통상적린지지단백가능시일충쌍층막결구，이비통상소인위적단층결구。
Phosphatidylcholines (PC) is one of the most important phospholipids in the human and animal serum. It is the major constituent of lipoproteins that play important roles in the transport and metabolism of cholesterol. It was found that the many diseases, such as atherosclerosis, cancer, dementia and so on, were often associated with compositional and structural changes of phospholipids. Therefore, it is of interest to study the composition and structure of phospholipids. Here, small unilamellar vesicles (SUV) formed by PC were studied using 1D and 2D NMR experiments. It was found that there were two different [-N+(CH3)3] signals of PC, indicating that the SUV formed by PC may have a bilayer-spherical structure, not as previously thought to be a mono-layer structure.