波谱学杂志
波譜學雜誌
파보학잡지
CHINESE JOURNAL OF MAGNETIC RESONANCE
2014年
4期
564-571
,共8页
核磁共振(NMR)%DMAP%布洛芬%手性硫脲%对映体纯度
覈磁共振(NMR)%DMAP%佈洛芬%手性硫脲%對映體純度
핵자공진(NMR)%DMAP%포락분%수성류뇨%대영체순도
NMR%DMAP%ibuprofen%chiral thiourea%enantiomeric purity
通过1H NMR 研究了手性硫脲对布洛芬类药物的手性识别．在4-二甲氨基吡啶(DMAP)的参与下，硫脲对布洛芬类化合物显示出良好的识别效果，并且布洛芬对映异构体的a-H NMR信号与硫脲和DMAP无相互干扰．为了检测硫脲/DMAP对手性布洛芬对映体纯度的分析能力，测定了若干ee.（对换体过量百分数）值的布洛芬溶液，与理论值吻合．
通過1H NMR 研究瞭手性硫脲對佈洛芬類藥物的手性識彆．在4-二甲氨基吡啶(DMAP)的參與下，硫脲對佈洛芬類化閤物顯示齣良好的識彆效果，併且佈洛芬對映異構體的a-H NMR信號與硫脲和DMAP無相互榦擾．為瞭檢測硫脲/DMAP對手性佈洛芬對映體純度的分析能力，測定瞭若榦ee.（對換體過量百分數）值的佈洛芬溶液，與理論值吻閤．
통과1H NMR 연구료수성류뇨대포락분류약물적수성식별．재4-이갑안기필정(DMAP)적삼여하，류뇨대포락분류화합물현시출량호적식별효과，병차포락분대영이구체적a-H NMR신호여류뇨화DMAP무상호간우．위료검측류뇨/DMAP대수성포락분대영체순도적분석능력，측정료약간ee.（대환체과량백분수）치적포락분용액，여이론치문합．
The chiral recognition of racemic ibuprofen by thiourea was studied using 1H NMR spectroscopy. It was found that, with the participation of DMAP, excellent recognition of the enantiomers of ibuprofen by thiourea could be achieved, and the process was not affected by the chiral bisthiourea and DMAP. To evaluate the ability of the chiral bisthiourea/DMAP for enantiomeric determination, several ee. values of ibuprofen samples were determined by 1H NMR, and the results coincided with the theoretical value.
