CAJ | 학술논문

目的：探讨左卡尼汀(蕴藻增燥糟葬则灶蚤贼蚤灶藻)联合1，6-二磷酸果糖(1，6-凿蚤责澡燥泽责澡葬贼藻，1，6-阅蚤责)治疗小儿病毒性心肌炎(责藻凿蚤葬贼则蚤糟增蚤则葬造皂赠燥糟葬则凿蚤贼蚤泽，孕灾M)临床疗效及安全性。方法对2011年3月年至2013年11月我科收治的病毒性心肌炎患儿66例进行回顾性分析，其中在常规治疗(休息、维生素)基础上联合1，6-阅蚤责者30例作为对照组，在基础治疗联合1，6-阅蚤责及左卡尼汀组36例作为试验组。治疗2周，比较两组患儿的临床疗效及不良反应。结果治疗2周后试验组与对照组临床总有效率分别为94.4豫和70.0豫，试验组显著高于对照组(孕<0.05)；与治疗前相比，治疗后两组患儿心肌酶均显著下降(孕<0.05)，但试验组下降程度更为明显(孕<0.05)；试验组治疗期间发生恶心呕吐1例，无其他不良反应。结论左卡尼汀联合1，6-二磷酸果糖治疗小儿病毒性心肌炎临床疗效确切，安全有效。
목적：탐토좌잡니정(온조증조조장칙조조적조조조)연합1，6-이린산과당(1，6-착조책조조택책조장적조，1，6-열조책)치료소인병독성심기염(책조착조장적칙조조증조칙장조조증조조장칙착조적조택，잉재M)림상료효급안전성。방법대2011년3월년지2013년11월아과수치적병독성심기염환인66례진행회고성분석，기중재상규치료(휴식、유생소)기출상연합1，6-열조책자30례작위대조조，재기출치료연합1，6-열조책급좌잡니정조36례작위시험조。치료2주，비교량조환인적림상료효급불량반응。결과치료2주후시험조여대조조림상총유효솔분별위94.4예화70.0예，시험조현저고우대조조(잉<0.05)；여치료전상비，치료후량조환인심기매균현저하강(잉<0.05)，단시험조하강정도경위명현(잉<0.05)；시험조치료기간발생악심구토1례，무기타불량반응。결론좌잡니정연합1，6-이린산과당치료소인병독성심기염림상료효학절，안전유효。
Objective To evaluate the clinical efficacy of Levocarnitine combined with 1, 6-diphosphate (1, 6-Dip) in the treatment of pediatric viral myocarditis (PVM). Methods 66 cases of pediatric viral myocarditis in our department from March 2011 to November 2013 were analyzed retrospectively. 30 cases of routine therapy combined with 1, 6-Dip were set as the control group, while 30 cases of routine therapy combined with 1, 6-Dip and Levocarnitine were set as the experiment group. After two weeks of treatment, the clinical efficacy and adverse reactions were compared between the two groups. Results After two weeks of treatment, the total effective rate was 94.4%of the experiment group, significantly higher than 70.0%of the control group (P <0.05). Cardiac enzymes significantly decreased in both groups after treatment (both P <0.05), but the decline degree of the experiment group was more significant (P <0.05). One case of nausea and vomiting occurred in the experimental group. Conclusions Levocarnitine combined with 1, 6-diphosphate in the treatment of pediatric viral myocarditis is effective and safe.