CAJ | 학술논문

目的：探讨血清基质金属蛋白酶-9(MMP-9)预测颅内外动脉血管内支架置入术后再狭窄的意义。方法选择40例接受颅内外动脉血管内支架置入术患者,分别在术前0.5 h,术后1、3 d,1、6、12个月抽取静脉血检测 MMP-9水平,观察术后再狭窄现象。结果和术前相比,术后患者血清MMP-9水平明显升高,术后3 d , MMP-9>正常参考值2.5倍的患者出现再狭窄的比率为30%(3/10), MMP-9<正常参考值2.5倍的患者未出现术后再狭窄；术后 MMP-9>正常参考值持续>30 d的患者出现再狭窄的比率为11.8%(2/17),持续<3 d的患者的比率为4.4%(1/23),但二者比较的差异无统计学意义(P>0.05)。结论颅内外动脉血管内支架置入术后3 d MMP-9>正常参考值2.5倍时,可能作为预测支架置入术后再狭窄的指标。
목적：탐토혈청기질금속단백매-9(MMP-9)예측로내외동맥혈관내지가치입술후재협착적의의。방법선택40례접수로내외동맥혈관내지가치입술환자,분별재술전0.5 h,술후1、3 d,1、6、12개월추취정맥혈검측 MMP-9수평,관찰술후재협착현상。결과화술전상비,술후환자혈청MMP-9수평명현승고,술후3 d , MMP-9>정상삼고치2.5배적환자출현재협착적비솔위30%(3/10), MMP-9<정상삼고치2.5배적환자미출현술후재협착；술후 MMP-9>정상삼고치지속>30 d적환자출현재협착적비솔위11.8%(2/17),지속<3 d적환자적비솔위4.4%(1/23),단이자비교적차이무통계학의의(P>0.05)。결론로내외동맥혈관내지가치입술후3 d MMP-9>정상삼고치2.5배시,가능작위예측지가치입술후재협착적지표。
Objective To investigate the effect of MMP-9 on predicting restenosis after intra and extra-cranial angioplasty and stenting. Methods In total, 40 patients underwent intra and extra-cranial angioplasty and stenting were chosen as subjects,and blood samples were taken at pre-operation and 1,3 d,1,6,12 months after surgery to measure the serum lev-els of MMP-9,and restenosis was observed simultaneously.Results Compared with pre-operation,the serum level of MMP-9 increased significantly at post-operation.The rate of restenosis was 30% (3/10)when the serum level of MMP-9 at the third day after surgery was 2.5 times higher than normal,and no restenosis happened when the serum level of MMP-9 at the third day after surgery was not 2.5 times higher than normal.The rate of restenosis was 11.8% (2/17)when the serum level of MMP-9 after surgery was higher than normal and last more than one month.The rate of restenosis was 4.4% (1/23)when that last less than one month.But the differences were not statistically significantly (P>0.05).Conclusion When the serum level of MMP-9 at the third day after intra and extra-cranial angioplasty and stenting is 2.5 times higher than normal,it may be as a predictor of in-stent restenosis.