听力学及言语疾病杂志
聽力學及言語疾病雜誌
은역학급언어질병잡지
JOURNAL OF AUDIOLOGY AND SPEECH PATHOLOGY
2014年
6期
600-602
,共3页
血小板平均体积%突发性聋%血栓性疾病
血小闆平均體積%突髮性聾%血栓性疾病
혈소판평균체적%돌발성롱%혈전성질병
Mean platelet volume%Sudden sensorineural hearing loss%Thrombotic vascular diseases
目的:分析突发性聋患者血小板平均体积(mean platelet volume,MPV)变化,初步探讨突发性聋的可能病因。方法以40例(40耳)突发性聋患者为研究对象(突聋组),其中轻度-中重度组(听力损失25~70 dB)15例(耳),重度-极重度组(听力损失≥71 dB)25例(耳),另选择30例健康成人为对照组,比较两组外周血中血小板计数(PLT)、血小板平均体积(MPV )、血小板分布宽度(PDW)的水平。结果突聋组血小板计数为212.0±47.9×109/L,对照组为237.8±46.2×109/L,突聋组低于对照组,差异有统计学意义(P<0.05);突聋组 MPV 为10.9±0.8 fL,对照组为10.3±0.8 fL,突聋组高于对照组,差异有统计学意义(P<0.05);突聋组 PDW 为12.9%±2.0%,对照组为12.0%±1.3%,突聋组高于对照组,差异有统计学意义(P<0.05)。突聋组中轻度-中重度组MPV 为11.0±1.1 fL,重度-极重度组 MPV 为10.8±1.0 fL,两组比较差异无统计学意义(P>0.05),两组 MPV分别与对照组比较,差异均有统计学意义(P<0.05)。结论MPV 是血栓性疾病发生的独立危险因素,突发性聋患者 MPV 升高可能与内听道血管缺血或血栓事件有关。
目的:分析突髮性聾患者血小闆平均體積(mean platelet volume,MPV)變化,初步探討突髮性聾的可能病因。方法以40例(40耳)突髮性聾患者為研究對象(突聾組),其中輕度-中重度組(聽力損失25~70 dB)15例(耳),重度-極重度組(聽力損失≥71 dB)25例(耳),另選擇30例健康成人為對照組,比較兩組外週血中血小闆計數(PLT)、血小闆平均體積(MPV )、血小闆分佈寬度(PDW)的水平。結果突聾組血小闆計數為212.0±47.9×109/L,對照組為237.8±46.2×109/L,突聾組低于對照組,差異有統計學意義(P<0.05);突聾組 MPV 為10.9±0.8 fL,對照組為10.3±0.8 fL,突聾組高于對照組,差異有統計學意義(P<0.05);突聾組 PDW 為12.9%±2.0%,對照組為12.0%±1.3%,突聾組高于對照組,差異有統計學意義(P<0.05)。突聾組中輕度-中重度組MPV 為11.0±1.1 fL,重度-極重度組 MPV 為10.8±1.0 fL,兩組比較差異無統計學意義(P>0.05),兩組 MPV分彆與對照組比較,差異均有統計學意義(P<0.05)。結論MPV 是血栓性疾病髮生的獨立危險因素,突髮性聾患者 MPV 升高可能與內聽道血管缺血或血栓事件有關。
목적:분석돌발성롱환자혈소판평균체적(mean platelet volume,MPV)변화,초보탐토돌발성롱적가능병인。방법이40례(40이)돌발성롱환자위연구대상(돌롱조),기중경도-중중도조(은력손실25~70 dB)15례(이),중도-겁중도조(은력손실≥71 dB)25례(이),령선택30례건강성인위대조조,비교량조외주혈중혈소판계수(PLT)、혈소판평균체적(MPV )、혈소판분포관도(PDW)적수평。결과돌롱조혈소판계수위212.0±47.9×109/L,대조조위237.8±46.2×109/L,돌롱조저우대조조,차이유통계학의의(P<0.05);돌롱조 MPV 위10.9±0.8 fL,대조조위10.3±0.8 fL,돌롱조고우대조조,차이유통계학의의(P<0.05);돌롱조 PDW 위12.9%±2.0%,대조조위12.0%±1.3%,돌롱조고우대조조,차이유통계학의의(P<0.05)。돌롱조중경도-중중도조MPV 위11.0±1.1 fL,중도-겁중도조 MPV 위10.8±1.0 fL,량조비교차이무통계학의의(P>0.05),량조 MPV분별여대조조비교,차이균유통계학의의(P<0.05)。결론MPV 시혈전성질병발생적독립위험인소,돌발성롱환자 MPV 승고가능여내은도혈관결혈혹혈전사건유관。
Objective Our aim was to investigate the association between sudden sensorineural hearing loss (SSHL)and mean platelet volume (MPV)values,in order to evaluate the etiology of SSHL.Methods This study included 40 patients with SSHL in our ward between Jan.2012 and Jan.2014 and 30 age- and sex-matched healthy subjects were included as controls.The correlation among the levels of the number of platelets,mean plate-let volume(MPV),platelet distribution width (PDW)was evaluated in the two groups.ResuIts The platelet count was significantly lower in the SSHL than the control group(212.0±47.9 versus 237.8±46.2 ×109/L).MPV and PDW were significantly higher in SSHL(10.9±0.8 versus 10.3±0.8 fL;12.9%±2.0% versus 12.0%±1.3 %). The SSHL patients were divided two subgroups:the mild-moderate subgroup (hearing loss 25~70 dB)and the se-vere subgroup(hearing loss≥70 dB).The MPV values were insignificantly different between the two subgroups(11. 0±1.1 fL versus 10.8 ±1.0 fL).Compared to the control group,the two subgroups had both significant differ-ences in MPV.ConcIusion High MPV values are a risk factor for thrombotic vascular diseases.Considering the in-creased MPV levels,SSHL appears to be characterized by ischaemic or thrombotic events.