CAJ | 학술논문

维 A 酸 X 受体（RXR）是配体依赖的核转录因子，在调节一系列生理病理过程中起重要作用。在分子水平上，RXR 与多个信号通路相互作用，调控细胞生长、分化、生存与死亡等靶基因的表达。RXR 信号通路网络与其他信号通路之间的相互作用使 RXR 成为抗肿瘤药物作用的新靶点。本文就 RXR 信号通路在白血病发生发展中的作用进行简要综述。
유 A 산 X 수체（RXR）시배체의뢰적핵전록인자，재조절일계렬생리병리과정중기중요작용。재분자수평상，RXR 여다개신호통로상호작용，조공세포생장、분화、생존여사망등파기인적표체。RXR 신호통로망락여기타신호통로지간적상호작용사 RXR 성위항종류약물작용적신파점。본문취 RXR 신호통로재백혈병발생발전중적작용진행간요종술。
Retinoid X receptor (RXR) acts as ligand-dependent transcription factors playing an important role in regulating a serial of physiological processes,such as embryo development and organ homeostasis.At the molecular level,RXRs exert their functions by inter-activating with multiple signal pathways to regulate target gene expression which control cell growth,differentiation,survival and death.The interference in the network of RXR and other signal pathways has turned RXR into an attractive drug target.