神经损伤与功能重建
神經損傷與功能重建
신경손상여공능중건
NEURAL INJURY AND FUNCTIONAL RECONSTRUCTION
2014年
6期
488-491
,共4页
周昊%徐蕾%王暖%黄红莉
週昊%徐蕾%王暖%黃紅莉
주호%서뢰%왕난%황홍리
帕罗西汀%白脉软膏%慢性紧张型头痛
帕囉西汀%白脈軟膏%慢性緊張型頭痛
파라서정%백맥연고%만성긴장형두통
Paroxetine%baimai recipe%chronic tension-type headache
目的：观察帕罗西汀联合白脉软膏治疗慢性紧张型头痛（CTH）的临床疗效。方法：CTH患者60例，随机分为给予帕罗西汀联合安慰剂软膏治疗的对照组和给予帕罗西汀联合白脉软膏治疗的观察组各30例，疗程8周。比较治疗前后患者外感受抑制实验（ESP）的第二潜伏期（ESP2）、时限及肌电频率、波幅变化，评价头痛程度、焦虑抑郁情绪及生活质量。结果：治疗后2组EPS2潜伏期明显缩短，时限明显延长（＜0.05），观察组较对照组更明显（＜0.05）。对照组肌电频率和波幅改变不明显（＞0.05），观察组肌电频率和波幅明显降低（＜0.05）。2组头痛程度、焦虑抑郁情绪评分明显低于治疗前，生活质量评分明显高于治疗前（＜0.05），观察组较对照组更明显（＜0.05）。结论：帕罗西汀联合白脉软膏治疗CTH疗效优于单用帕罗西汀。
目的：觀察帕囉西汀聯閤白脈軟膏治療慢性緊張型頭痛（CTH）的臨床療效。方法：CTH患者60例，隨機分為給予帕囉西汀聯閤安慰劑軟膏治療的對照組和給予帕囉西汀聯閤白脈軟膏治療的觀察組各30例，療程8週。比較治療前後患者外感受抑製實驗（ESP）的第二潛伏期（ESP2）、時限及肌電頻率、波幅變化，評價頭痛程度、焦慮抑鬱情緒及生活質量。結果：治療後2組EPS2潛伏期明顯縮短，時限明顯延長（＜0.05），觀察組較對照組更明顯（＜0.05）。對照組肌電頻率和波幅改變不明顯（＞0.05），觀察組肌電頻率和波幅明顯降低（＜0.05）。2組頭痛程度、焦慮抑鬱情緒評分明顯低于治療前，生活質量評分明顯高于治療前（＜0.05），觀察組較對照組更明顯（＜0.05）。結論：帕囉西汀聯閤白脈軟膏治療CTH療效優于單用帕囉西汀。
목적：관찰파라서정연합백맥연고치료만성긴장형두통（CTH）적림상료효。방법：CTH환자60례，수궤분위급여파라서정연합안위제연고치료적대조조화급여파라서정연합백맥연고치료적관찰조각30례，료정8주。비교치료전후환자외감수억제실험（ESP）적제이잠복기（ESP2）、시한급기전빈솔、파폭변화，평개두통정도、초필억욱정서급생활질량。결과：치료후2조EPS2잠복기명현축단，시한명현연장（＜0.05），관찰조교대조조경명현（＜0.05）。대조조기전빈솔화파폭개변불명현（＞0.05），관찰조기전빈솔화파폭명현강저（＜0.05）。2조두통정도、초필억욱정서평분명현저우치료전，생활질량평분명현고우치료전（＜0.05），관찰조교대조조경명현（＜0.05）。결론：파라서정연합백맥연고치료CTH료효우우단용파라서정。
Objective:To observe the clinical effect of Paroxetine combined with baimai recipe on the treatment of chronic tension-type headache (CTH). Methods:Sixty CTH patients were randomly divided into observation group treated with Paroxetine combined with baimai recipe and control group treated with Paroxetine combined with placebo recipe(n=30) with the course of treatment of 8 weeks. The second latency (ESP2), time limit, electromyo-gram frequency and amplitude variation of exteroceptive suppression experiment (ESP) in patients before and after treatment were measured. The emotion and quality of life of headache severity, anxiety and depression were evalu-ated. Results:The patients in the two groups presented significantly decreased EPS2 latency and prolonged time limit after treatment compared with those before treatment ( <0.05). The electromyogram frequency and amplitude had no obvious change in control group, which showed obvious reduction in observation group. The headache degree and anxiety and depression score was significantly lower and the quality of life score was significantly higher than those before treatment ( <0.05). After the treatment, the ESP2 latency and time limit in the observation group were shorter than the control group ( <0.05). The headache degree and anxiety and depression score was significantly lower in the observation group than that of the control group ( <0.05). The quality of life score was significantly higher in the observation group than that in the control group ( <0.05). Conclusion:The clinical effect of Paroxetine combined with baimai was better than that using a single Paroxetine in the treatment of CTH.
