CAJ | 학술논문

目的：探讨神经性肌强直（NMT）的临床表现、肌电图及治疗特点。方法：回顾性分析临床确诊的4例NMT患者的临床表现、肌电图及治疗特点。结果：4例患者临床表现均以静息状态下肌肉颤搐为主，肌电图显示自发的、连续的、不规则的多重单个运动单元高频率放电，其中3例单纯卡马西平或苯妥英钠效果不佳，加用激素治疗后获痊愈。结论：卡马西平或苯妥英钠治疗获得性NMT可缓解症状，效果不佳时结合激素治疗，疗效显著，支持获得性NMT与免疫功能紊乱相关。
목적：탐토신경성기강직（NMT）적림상표현、기전도급치료특점。방법：회고성분석림상학진적4례NMT환자적림상표현、기전도급치료특점。결과：4례환자림상표현균이정식상태하기육전휵위주，기전도현시자발적、련속적、불규칙적다중단개운동단원고빈솔방전，기중3례단순잡마서평혹분타영납효과불가，가용격소치료후획전유。결론：잡마서평혹분타영납치료획득성NMT가완해증상，효과불가시결합격소치료，료효현저，지지획득성NMT여면역공능문란상관。
Objective: To investigate the characteristics of neuromyotonia in clinical manifestation, electromyo-graphic features and treatment. Methods:The clinical manifestation, electromyographic features and treatment of four neuromyotonia cases were analyzed. Results:The four patients manifested muscle twitching at rest and EMG revealed spontaneous, continuous, irregularly occurring multiple motor unit discharges, firing at high frequency. Three out of the four patients were not cured by anti-epilepsy drugs such as Carbamazepine or Phenytoin before prednisone was added. Conclusion:The symptoms of acquired neuromyotonia can be alleviated by Carbamazepine or Phenytoin. The remarkable effect may be achieved by prednisone. The data supports the evidence that the ac-quired neuromyotonia is a disorders of mediated by autoimmunity.