CAJ | 학술논문

目的：建立高温高湿条件下猪脊髓火器伤模型，观察受伤节段脊髓的病理变化。方法：选用6头南方实验用猪构建高温高湿条件下胸腰段脊髓高能火器伤模型，伤时及6h后取脊髓组织观察其病理形态学改变。结果：大体观察符合高能量火器伤损伤特点，伤后镜下均可见脊髓硬脊膜血管扩张，硬膜下淤血明显，灰质中神经元细胞变性等改变，6h后神经元消失溶解，灰质神经元尼氏体大量发生崩解。结论：采用适龄猪建立高温高湿环境下脊髓火器伤模型，造模稳定，重复性较好。
목적：건립고온고습조건하저척수화기상모형，관찰수상절단척수적병리변화。방법：선용6두남방실험용저구건고온고습조건하흉요단척수고능화기상모형，상시급6h후취척수조직관찰기병리형태학개변。결과：대체관찰부합고능량화기상손상특점，상후경하균가견척수경척막혈관확장，경막하어혈명현，회질중신경원세포변성등개변，6h후신경원소실용해，회질신경원니씨체대량발생붕해。결론：채용괄령저건립고온고습배경하척수화기상모형，조모은정，중복성교호。
Objective:To establish the firearm injury model in the environment of high temperature and humidity and to study the pathological changes of the spinal cord after injury. Methods:Six healthy porcine were subjected to SCI models with high-energy gunshot in spinal cord of breast and lumbar section. The pathological changes of spinal cord were observed under optical microscopy (OM) immediately and six hours after surgery. Results:The general pathological changes were in agreement with high-energy ignition injury damage characteristics. Under OM, the blood vessels of spinal dura mater were dilated; subdural blood congestion were obvious, and neuronal cells in grey matter were degenerated, disappeared and dissolved;gray Nissl body mass were collpsed. Conclusion:The model was established with good stability and reproducibility.