CAJ | 학술논문

促红细胞生成素（EPO）为165个氨基酸残基组成的糖蛋白，主要由胎肝和成人肾皮质的成纤维细胞生成。EPO的表达受到多种转录因子和表观遗传学调控。EPO与其受体结合后主要通过激活Jak2／stat5通路，进而激活 Pim、c-Myc、OncostatinM、Bcl-2、Bcl-xL、SOCS 和 D-type cyclin 等基因，在红细胞生成过程中起到抗细胞凋亡和促进细胞增殖等重要作用。使用促红细胞生成剂上调血红蛋白含量，进而改善贫血患者的能量水平和生活质量具有重要意义，但长期使用存在一些副作用。本文对EPO表达调控机制及其在贫血治疗中的应用进行论述。
촉홍세포생성소（EPO）위165개안기산잔기조성적당단백，주요유태간화성인신피질적성섬유세포생성。EPO적표체수도다충전록인자화표관유전학조공。EPO여기수체결합후주요통과격활Jak2／stat5통로，진이격활 Pim、c-Myc、OncostatinM、Bcl-2、Bcl-xL、SOCS 화 D-type cyclin 등기인，재홍세포생성과정중기도항세포조망화촉진세포증식등중요작용。사용촉홍세포생성제상조혈홍단백함량，진이개선빈혈환자적능량수평화생활질량구유중요의의，단장기사용존재일사부작용。본문대EPO표체조공궤제급기재빈혈치료중적응용진행논술。
Erythropoietin (EPO) is a glycoprotein composed of 165 amino acid residue that is mainly produced in the fetal liver and adult kidney cortex fibroblast. The binding of EPO and its receptor can activate Jak2/stat5 pathway. Several important Stat5 target genes, such as Pim, c-Myc, OncostatinM, Bcl-xL SOCS or D-type cyclins are required for functional erythropoiesis. The expression of EPO is regulated by a variety of transcription factors and epigenetic regulation. Erythropoiesis-stimulating agents (ESA) can increase hemoglobin levels, and thus improve the energy level and quality of life in patients with anemia, but the long-term use of ESA also has some side effects. In this paper, the EPO expression regulation mechanism and its application in the treatment of anemia of chronic disease is discussed.