CAJ | 학술논문

目的：扩散加权成像(DWI)评估索拉非尼治疗大鼠肝癌的疗效。方法造模成功的 Wistar 大鼠分为实验组及对照组,分别给予索拉非尼及生理盐水灌胃治疗,连续21 d。治疗前后行 MRI 检查。观察2组大鼠治疗前后肿瘤大小、ADC 值的变化。检查结束后,处死大鼠行病理学检查并进行相关性分析。结果①实验组治疗后肿瘤变小。②实验组各个 b 值下,治疗后 ADC 值增大。b 值为50 s/mm2时,治疗前后 ADC 值的差值最大,实验组与对照组治疗前后 ADC 值的差值的差距最大。③ HE 染色显示实验组治疗后肿瘤出现灶性坏死。实验组治疗后肿瘤血管密度减低,VEGF 染色呈低表达。MVD 与 VEGF 与 ADC 值的变化具有相关性。结论索拉非尼治疗大鼠肝癌有效,DWI 成像能客观评估索拉非尼治疗大鼠肝癌的有效性。
목적：확산가권성상(DWI)평고색랍비니치료대서간암적료효。방법조모성공적 Wistar 대서분위실험조급대조조,분별급여색랍비니급생리염수관위치료,련속21 d。치료전후행 MRI 검사。관찰2조대서치료전후종류대소、ADC 치적변화。검사결속후,처사대서행병이학검사병진행상관성분석。결과①실험조치료후종류변소。②실험조각개 b 치하,치료후 ADC 치증대。b 치위50 s/mm2시,치료전후 ADC 치적차치최대,실험조여대조조치료전후 ADC 치적차치적차거최대。③ HE 염색현시실험조치료후종류출현조성배사。실험조치료후종류혈관밀도감저,VEGF 염색정저표체。MVD 여 VEGF 여 ADC 치적변화구유상관성。결론색랍비니치료대서간암유효,DWI 성상능객관평고색랍비니치료대서간암적유효성。
Objective To evaluate the therapeutic effect of sorafenib for hepatocellular carcinoma in rats by using diffusion-weigh-ted imaging (DWI).Methods Wistar rats were divided into an experimental group (n=30)and a control group (n=10).The rats were gavaged with sorafenib and saline for 21 days respectively and then were scanned by MRI before and after treatment.The chan-ges of tumors’size and the ADC values before and after treatment in two groups were observed.After the examination,the rats were killed for pathological results.Results In the experimental group,the size of tumor became smaller after treatment,however the ADC value was opposite under each b value.When the b value was set at 50 s/mm2 ,the difference in ADC values and the gap between ADC values of difference between experimental and control groups were the largest.HE staining showed focal necrosis in the tumor after treatment.Significantly decreased MVD and low VEGF expression were showed after treatment.The correlation be-tween MVD,VEGF and the changes of the ADC values was also showed.Conclusion Sorafenib may treat liver cancer effectively and its therapeutic effect can be assessed by DWI well.