CAJ | 학술논문

目的：采用静息态下低频振幅(ALFF)与功能连接的方法，观察长期使用海洛因对大脑相关脑区局部神经元的基线活动影响，并分析这些相关脑区神经活动改变与大脑功能组织模式的关系。方法采集17例海洛因依赖者和15例正常被试者的 fMRI 数据，分析海洛因依赖者 ALFF 的变化及其与使用海洛因的关系。以产生差异脑区为感兴趣区，用功能连接方法分析海洛因依赖者功能连接的改变。结果与对照组相比，海洛因依赖者的右侧尾状核、右背侧前扣带回、右额上回的 ALFF 明显降低，而双侧小脑、左颞上回和左枕上回 ALFF 增加。以上脑区中，仅右侧尾状核的 ALFF 值与海洛因使用总时间及每日剂量呈负相关。功能连接分析显示右侧尾状核和背外侧前额叶皮层(dlPFC)的功能连接降低，与小脑的功能连接增强。结论海洛因依赖者基线水平大脑神经元ALFF 减少伴随着大脑功能连接的失调；慢性海洛因依赖者前额-纹状体环路和前额-小脑环路功能失调，后者支持小脑内部模型理论以及促成成瘾者从机械行为向成瘾习惯的转换。
목적：채용정식태하저빈진폭(ALFF)여공능련접적방법，관찰장기사용해락인대대뇌상관뇌구국부신경원적기선활동영향，병분석저사상관뇌구신경활동개변여대뇌공능조직모식적관계。방법채집17례해락인의뢰자화15례정상피시자적 fMRI 수거，분석해락인의뢰자 ALFF 적변화급기여사용해락인적관계。이산생차이뇌구위감흥취구，용공능련접방법분석해락인의뢰자공능련접적개변。결과여대조조상비，해락인의뢰자적우측미상핵、우배측전구대회、우액상회적 ALFF 명현강저，이쌍측소뇌、좌섭상회화좌침상회 ALFF 증가。이상뇌구중，부우측미상핵적 ALFF 치여해락인사용총시간급매일제량정부상관。공능련접분석현시우측미상핵화배외측전액협피층(dlPFC)적공능련접강저，여소뇌적공능련접증강。결론해락인의뢰자기선수평대뇌신경원ALFF 감소반수착대뇌공능련접적실조；만성해락인의뢰자전액-문상체배로화전액-소뇌배로공능실조，후자지지소뇌내부모형이론이급촉성성은자종궤계행위향성은습관적전환。
Objective To explore heroin-induced damages on partial neural activities,and to analyze the relationship between these damages and the brain mode in functional organizationby observing its resting-state amplitude of low-frequency fluctuation (ALFF)and functional connectivity.Methods Gathering fMRI scans of 1 7 male heroin dependent individuals and 1 5 equivalent nor-mal subjects at their resting-state,using Rest and Dparsf software to analyze changes of ALFF in the brain regions of heroin depend-ent individuals;the relationship between ALFF changes with these individual’s previous heroin consuming state was also analyzed. Then taking the differentiated brain parts as ROI,using functional connectivity method to analyze the changes of the connections of addiction-related alteration in the whole brain in the heroin dependent individuals.Results Compared with normal control group,the ALFF of heroin dependent individuals was reduced in the right caudate,right superior medial frontal cortex,and right dorsal anterior cingulate cortex (dACC),while increased in the left superior temporal gyrus,bilateral cerebellum,and left superior occipital gyrus. In these brain regions,only the value of the right caudate ALFF had a negative correlation with the overall time of heroin use.The functional connectivity between right caudate and dorsolateral prefrontal cortex (dlPFC)was reduced,while the functional connectiv-ity between the right caudate and cerebellum was increased.Conclusion The reduction of ALFF and dysfunction of functional con-nectivity in heroin dependent individuals,and the dysfunction in the fronto-striatal and fronto-cerebell circuit,which may support the cerebellar internal model theory and contribute to the transformation from mechanical behaviors to addictive habits.