CAJ | 학술논문

目的：应用纤维束成像术研究遗忘型轻度认知功能障碍(aMCI)患者脑白质细微结构的改变。方法对30例经临床诊断的 aMCI 患者和31例正常对照(NC)组行扩散张量成像，用 dTV II 软件重建出扣带束、胼胝体、钩状束及下枕额束，并沿着白质束测量部分各向异性(FA)值。对比分析 aMCI 组与 NC 组各白质束的 FA 值，并将 aMCI 组的 FA 值与简易智能精神状态检查量表(MMSE)评分进行相关性分析。结果①aMCI 组的两侧扣带束、两侧钩状束及胼胝体 FA 值明显低于 NC 组，差异有统计学意义；左侧下枕额束 FA 值低于 NC 组，但差异无统计学意义。②右侧扣带束的 FA 值与 MMSE 评分呈正相关。结论aMCI 患者扣带束、钩状束及胼胝体 FA 值的异常改变，提示在阿尔茨海默病(AD)的前驱阶段存在与记忆相关的脑白质束的微损害，纤维束成像(tractography)技术对脑白质的早期损害具有很高的敏感性。
목적：응용섬유속성상술연구유망형경도인지공능장애(aMCI)환자뇌백질세미결구적개변。방법대30례경림상진단적 aMCI 환자화31례정상대조(NC)조행확산장량성상，용 dTV II 연건중건출구대속、변지체、구상속급하침액속，병연착백질속측량부분각향이성(FA)치。대비분석 aMCI 조여 NC 조각백질속적 FA 치，병장 aMCI 조적 FA 치여간역지능정신상태검사량표(MMSE)평분진행상관성분석。결과①aMCI 조적량측구대속、량측구상속급변지체 FA 치명현저우 NC 조，차이유통계학의의；좌측하침액속 FA 치저우 NC 조，단차이무통계학의의。②우측구대속적 FA 치여 MMSE 평분정정상관。결론aMCI 환자구대속、구상속급변지체 FA 치적이상개변，제시재아이자해묵병(AD)적전구계단존재여기억상관적뇌백질속적미손해，섬유속성상(tractography)기술대뇌백질적조기손해구유흔고적민감성。
Objective To investigate subtle structural changes of white matter in patients with amnestic mild cognitive impair-ment (aMCI)using a tractography-based method.Methods Thirty patients with clinical diagnosis of aMCI and thirty-one cases of normal control(NC)and undergone diffusion tensor imaging.Cingulum (CG),corpus callosum (CC),uncinate fasciculus (UNC) and inferior occipitofrontal fasciculus (IOFF)were reconstructed,and fractional anisotrophy (FA)values were measured along these tracts using dTV II software.Differences of white matter tracts’FA values were explored between aMCI group and NC group.In addition,correlation analyses were also done between FA values and the MMSE(mini-mental state examination)scores in the aMCI patients.Results ① aMCI patients exhibited significant lower FA values in the bilateral CG,bilateral UNC and CC than NC group. Although there were no statistically significant differences,aMCI patients exhibited lower FA values than NC group in the left IOFF.② The FA values of right CG were positively correlated with MMSE scores.Conclusion Abnormal changes of FA values in CG,UNC and CC of aMCI patients suggest that subtle damages of white matter tracts related to memory exist in the prodromal phase of Alzheimer’s disease (AD).Fiber tractography has high sensitivity in detecting early damages of white matter.