CAJ | 학술논문

目的：探讨小剂量盐酸羟考酮缓释片（奥施康定）治疗晚期肺癌中度癌痛的疗效和安全性。方法将60例晚期肺癌合并中度癌痛患者随机分为对照组（30例）和治疗组（30例），对照组采用盐酸曲马多缓释片（奇曼丁，起始剂量100 mg/次、每12小时一次）治疗，治疗组采用奥施康定（起始剂量10 mg/次、每12小时一次）治疗，2组出现爆发痛时加用盐酸吗啡片滴定，次日加大剂量，直至疼痛NRS评分≤3分。至少治疗2周后评价临床疗效和不良反应。结果60例患者均可进行客观疗效评价及不良反应观察。治疗组CR 10例，PR 18例，MR 1例，NR 1例，治疗组客观有效率（RR）93．33％；对照组CR 7例，PR 20例，MR 1例，NR 2例，对照组客观有效率（RR）90．00％；与对照组相比较，治疗组的客观有效率及不良反应发生率差异无统计学意义（P＞0．05），但奥施康定起效更迅速（P＝0．015）、达稳态剂量更小（P＜0．001）。结论小剂量奥施康定治疗晚期肺癌中度癌痛有效、安全。
목적：탐토소제량염산간고동완석편（오시강정）치료만기폐암중도암통적료효화안전성。방법장60례만기폐암합병중도암통환자수궤분위대조조（30례）화치료조（30례），대조조채용염산곡마다완석편（기만정，기시제량100 mg/차、매12소시일차）치료，치료조채용오시강정（기시제량10 mg/차、매12소시일차）치료，2조출현폭발통시가용염산마배편적정，차일가대제량，직지동통NRS평분≤3분。지소치료2주후평개림상료효화불량반응。결과60례환자균가진행객관료효평개급불량반응관찰。치료조CR 10례，PR 18례，MR 1례，NR 1례，치료조객관유효솔（RR）93．33％；대조조CR 7례，PR 20례，MR 1례，NR 2례，대조조객관유효솔（RR）90．00％；여대조조상비교，치료조적객관유효솔급불량반응발생솔차이무통계학의의（P＞0．05），단오시강정기효경신속（P＝0．015）、체은태제량경소（P＜0．001）。결론소제량오시강정치료만기폐암중도암통유효、안전。
Objective To study the clinical efficacy and safety of small-doses oxycodone hydrochloride ( oxycontin ) in the treatment of advanced lung cancer moderate cancerous pain. Methods 60 cases of patients with advanced lung cancer moder-ate cancerous pain were randomly divided into the treatment group and the control group, each with 30 cases.The control group was treated with tramadol hydrochloride (tramcontin,initial dose of 100 mg every 12 hours),and the treatment group was treated with oxycontin(initial dose of 10 mg every 12 hours),morphine hydrochloride was used for titration when outbreaking of cancer pain in the 2 groups, increasing the dose next day until the pain NRS score was 3 points or less, the clinical efficacy and adverse reactions were evaluated at least 2 weeks later. Results 60 cases of patients could be given an objective evaluation of the efficacy and adverse reactions. Among the treatment group, there were 10 cases of CR,18 cases of PR,1 case of MR,1 case of NR,and ob-jective response rate (RR) was 93.33%,among the control group,CR was 7 cases,PR 20 cases,MR 1 case,NR 2 cases,and ob-jective response rate was 90.00%.The 2 groups had no statistical difference in objective efficicacy and incidence of adverse reac -tions (P>0.05),but oxycontin had faster action of onset (P=0.015),and dose of steady state was smaller(P<0.001).Con-clusion Small-doses of oxycontin for advanced lung cancer moderate pain has good efficacy and safety.