CAJ | 학술논문

目的：探讨恒温快速冷冻切片对乳腺癌组织中CerbB-2蛋白表达的影响。方法应用MaxVinsion免疫组织化学技术，对130例浸润性导管癌患者的恒温冷冻切片对应组织和剩余组织石蜡标本进行标记，比较两组CerbB-2蛋白表达情况。结果130例浸润性导管癌冰冻切片对应组织样本组中42例CerbB-2表达阴性，33例CerbB-2表达＋，34例CerbB-2表达＋＋，21例CerbB-2表达＋＋＋；剩余组织常规切片样本组56例CerbB-2表达阴性，50例CerbB-2表达＋，19例CerbB-2表达＋＋，5例CerbB-2表达＋＋＋；两组标记结果比较具有非常显著性差异，而且两组CerbB-2阳性表达结果一致性较差。结论恒温快速冷冻切片影响乳腺癌组织中CerbB-2蛋白表达，减弱乳腺癌组织中CerbB-2蛋白阳性表达。
목적：탐토항온쾌속냉동절편대유선암조직중CerbB-2단백표체적영향。방법응용MaxVinsion면역조직화학기술，대130례침윤성도관암환자적항온냉동절편대응조직화잉여조직석사표본진행표기，비교량조CerbB-2단백표체정황。결과130례침윤성도관암빙동절편대응조직양본조중42례CerbB-2표체음성，33례CerbB-2표체＋，34례CerbB-2표체＋＋，21례CerbB-2표체＋＋＋；잉여조직상규절편양본조56례CerbB-2표체음성，50례CerbB-2표체＋，19례CerbB-2표체＋＋，5례CerbB-2표체＋＋＋；량조표기결과비교구유비상현저성차이，이차량조CerbB-2양성표체결과일치성교차。결론항온쾌속냉동절편영향유선암조직중CerbB-2단백표체，감약유선암조직중CerbB-2단백양성표체。
Objective To explore the influence of frozen section on the expression of CerbB-2 in patients with advanced breast cancer .Methods The CerbB-2 expression of tissues after frozen section and the rest tissues in 130 cases of advanced breast cancer were detected by Max vinsion immunohistochemistry ,and the difference of the 2 groups were compared .Results There ware 42 cases of CerbB-2 negative expression ,33 cases of CerbB-2+expression ,34 cases of CerbB-2++expression and 21 cases of CerbB-2+++expression in the frozen section group .There were 56 cases of CerbB-2 negative expression ,50 cases of CerbB-2+expression,19 cases of CerbB-2++expression and 5 cases of CerbB-2+++expression in the rest tissues by routine section .The difference of the CerbB-2 expression of the 2 groups was significant , and the CerbB-2 expression of the 2 groups had low degree of consistency .Conclusion The frozen section affects the CerbB-2 expression in the advanced breast cancer,and decreases the CerbB-2 expression.