CAJ | 학술논문

目的：制备抗癫疒间肽纳米粒,并研究其体外释药性能。方法选用聚乙二醇-聚乳酸-聚乙醇酸嵌段共聚物为载体,采用复乳-溶剂挥发法制备抗癫疒间肽纳米粒,以包封率、载药量等指标优化制备工艺,并研究纳米粒体外释药性能。结果抗癫疒间肽纳米粒外观呈圆形或类圆形,平均粒径为(100．2±2．45)nm,包封率和载药量分别为(64．46±1．34)%和(4．73±0．32)%,体外释药呈现缓释和突释两个阶段,符合Weibull方程。结论建立的制备工艺简便可行,得到的抗癫疒间肽纳米粒包封率和载药量较高,粒径小,体外释药具有明显的缓释特征。
목적：제비항전녁간태납미립,병연구기체외석약성능。방법선용취을이순-취유산-취을순산감단공취물위재체,채용복유-용제휘발법제비항전녁간태납미립,이포봉솔、재약량등지표우화제비공예,병연구납미립체외석약성능。결과항전녁간태납미립외관정원형혹류원형,평균립경위(100．2±2．45)nm,포봉솔화재약량분별위(64．46±1．34)%화(4．73±0．32)%,체외석약정현완석화돌석량개계단,부합Weibull방정。결론건립적제비공예간편가행,득도적항전녁간태납미립포봉솔화재약량교고,립경소,체외석약구유명현적완석특정。
Objective To prepare anti-epilepsy peptide nanoparticles and evaluate its release characteristics in vitr. Methods Anti-epilepsy peptide nanoparticles were prepared by emulsion/solvent evaporation method and poly (ethylene glycol)-poly(lactide acid)-poly(glycolic acid)copolymer was used as carrier material. Encapsulation effi-ciency and drug loading were used to optimize the technique and evaluate its release characteristics in vitro. Results The appearance of all anti-epilepsy peptide nanoparticles were round or similar. The mean particle size,encapsulation efficiency and drug loading of anti-epilepsy peptide nanoparticles were ( 100. 2 ± 2. 45 ) nm, ( 64. 46 ± 1. 34 )% and (4. 73 ± 0. 32)%respectively. The drug release from nanoparticles appeared consisting of two phases with initial burst release and sustained-release in vitro,and the release rule accorded with Weibull equation. Conclusion The preparation technics is simple and feasible,and the obtained anti-epilepsy peptide nanoparticles has high encapsulation efficiency, high drug loading,small mean diameter and the drug releasing characteristic is sustained in vitro.