CAJ | 학술논문

目的：探讨妊娠期高血压疾病患者外周血凋亡相关因子浓度的变化情况。方法选择我院妊娠期高血压疾病38例作为妊娠期高血压组,选择同期正常妊娠期妇女24例作为正常妊娠组；另根据病情严重程度将妊娠期高血压疾病患者分为妊娠期高血压组(14例)、轻度子痫前期组(14例)和重度子痫前期组(10例)3组。所有研究对象均行剖宫产术,术前检测并比较妊娠期高血压疾病组与正常妊娠组及不同程度妊娠期高血压疾病3组间外周血血管内皮生长因子( vascular endothelial growth factor, VEGF)、胎盘生长因子( placenta growth factor, PLGF)及GATA-3浓度。结果妊娠期高血压疾病组外周血中VEGF及PLGF浓度均低于正常妊娠组,GATA-3浓度高于正常妊娠组,两组比较差异均具有统计学意义(P<0．05)；不同程度妊娠期高血压疾病3组随病情严重程度增加外周血中VEGF及PLGF浓度逐渐降低,GATA-3浓度逐渐升高,3组间两两比较差异均有统计学意义( P<0．05)。相关性分析结果显示轻度子痫前期组及重度子痫前期组外周血 GATA-3浓度与 VEGF 浓度均呈负相关( r =-0.681, P =0.044；r =-0.741,P=0.041)。结论外周血中凋亡相关因子浓度失衡是妊娠期高血压疾病发病的相关因素。
목적：탐토임신기고혈압질병환자외주혈조망상관인자농도적변화정황。방법선택아원임신기고혈압질병38례작위임신기고혈압조,선택동기정상임신기부녀24례작위정상임신조；령근거병정엄중정도장임신기고혈압질병환자분위임신기고혈압조(14례)、경도자간전기조(14례)화중도자간전기조(10례)3조。소유연구대상균행부궁산술,술전검측병비교임신기고혈압질병조여정상임신조급불동정도임신기고혈압질병3조간외주혈혈관내피생장인자( vascular endothelial growth factor, VEGF)、태반생장인자( placenta growth factor, PLGF)급GATA-3농도。결과임신기고혈압질병조외주혈중VEGF급PLGF농도균저우정상임신조,GATA-3농도고우정상임신조,량조비교차이균구유통계학의의(P<0．05)；불동정도임신기고혈압질병3조수병정엄중정도증가외주혈중VEGF급PLGF농도축점강저,GATA-3농도축점승고,3조간량량비교차이균유통계학의의( P<0．05)。상관성분석결과현시경도자간전기조급중도자간전기조외주혈 GATA-3농도여 VEGF 농도균정부상관( r =-0.681, P =0.044；r =-0.741,P=0.041)。결론외주혈중조망상관인자농도실형시임신기고혈압질병발병적상관인소。
Objective To investigate the changes of apoptosis-related factors in peripheral serum of patients with hy-pertensive disorder complicating pregnancy. Methods A total of 38 patients who suffered from gestational hypertension were chosen as hypertensive disorder complicating pregnancy group and 24 normal pregnant women were chosen as normal pregnancy group. The patients in hypertensive disorder complicating pregnancy group were divided into three groups: gestational hyper-tension group (14 patients), mild preeclampsia group (14 patients) and severe preeclampsia group (10 patients). Before ce-sarean section, vascular endothelial growth factor ( VEGF) , placenta growth factor ( PLGF) and GATA-3 in the normal preg-nancy group and hypertensive disorder complicating pregnancy group were detected for comparisons. Results The concentra-tions of VEGF and PLGF were markedly lower in hypertensive disorder complicating pregnancy group than those in normal pregnancy group, but GATA-3 was higher than that in normal pregnancy group, and the differences were all significant ( P<0. 05 ) . Peripheral blood concentrations of VEGF and PLGF in the 3 groups of gestational hypertension disease decreased with the degree of the disease, but GATA-3 concentration increased, and the differences among the three groups showed signifi-cance (P<0. 05). Correlation analysis results showed that GATA-3 was negatively related to VEGF between the mild and se-vere preeclampsia group (r= -0. 681, P=0. 044; r= -0. 741, P=0. 041). Conclusion Unbalanced peripheral blood concentration of apoptosis-related factors may be related to gestational hypertension disease.