CAJ | 학술논문

目的：观察鼠李柠檬素的抗炎作用,为寻找镰形棘豆抗炎活性成分提供实验依据。方法分别将昆明种小鼠及Wistar大鼠,随机分为模型组、萘普生组和鼠李柠檬素高、中、低剂量组,灌胃给药,连续7 d。通过二甲苯诱导小鼠耳肿胀、冰醋酸诱导小鼠腹腔毛细管通透性、蛋清致大鼠足跖肿胀、棉球致大鼠肉芽肿的方法,观察鼠李柠檬素对急慢性炎症动物模型的影响。结果鼠李柠檬素各剂量组和萘普生组对上述4种方法所致的炎症反应有一定的抑制作用,与模型组比较差异有统计学意义(P＜0.05)。其中鼠李柠檬素高剂量组和萘普生组对肿胀的抑制作用较强,2组比较差异有统计学意义(P＜0.05)。结论鼠李柠檬素具有一定的抗炎作用,是镰形棘豆发挥抗炎作用的重要成分之一。
목적：관찰서리저몽소적항염작용,위심조렴형극두항염활성성분제공실험의거。방법분별장곤명충소서급Wistar대서,수궤분위모형조、내보생조화서리저몽소고、중、저제량조,관위급약,련속7 d。통과이갑분유도소서이종창、빙작산유도소서복강모세관통투성、단청치대서족척종창、면구치대서육아종적방법,관찰서리저몽소대급만성염증동물모형적영향。결과서리저몽소각제량조화내보생조대상술4충방법소치적염증반응유일정적억제작용,여모형조비교차이유통계학의의(P＜0.05)。기중서리저몽소고제량조화내보생조대종창적억제작용교강,2조비교차이유통계학의의(P＜0.05)。결론서리저몽소구유일정적항염작용,시렴형극두발휘항염작용적중요성분지일。
Objective To observe the anti-inflammatory effects of rhamnocitrin in Oxytropis falcata Bunge;To provide experimental evidence for searching the anti-inflammatory active component of Oxytropis falcata Bunge. Methods Kunming mice or Wistar rats were randomly divided into model group, naproxen group and rhamnocitrin high-, medium-, low-dose groups, and corresponding medicines were administered by gavage for 7 days. Animal inflammatory models were established respectively by the mice ear swelling induced by dimethylbenzene, the mice abdominal capillary permeability induced by acetic acid, the rat paw edema created by injection of albumen and the rat granuloma induced by cotton pellet wool. The effects of rhamnocitrin on acute and chronic inflammatory animal models were observed. Results Different doses of rhamnocitrin groups could reduce the animal ear swelling, abdominal capillary permeability, paw edema and granuloma. Compared with the model group, there were obvious differences in rhamnocitrin groups (P<0.05). High dose rhamnocitrin group and naproxen group showed relatively strong inhibition effects on swelling, with statistical significance (P<0.05). Conclusion Rhamnocitrin has anti-inflammatory effects and is an important biological component of Oxytropis falcata Bunge.